抗癌剤および血管新生阻害剤による口腔扁平上皮癌の浸潤・転移抑制効果

Material type: 文書・図像類

Author: 川尻, 秀一ほか

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Publication date: 2011-05-18

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Note (General)：: 金沢大学医薬保健研究域医学系口腔扁平上皮癌の臨床での浸潤および転移を忠実に再現できるマウス正所性移植モデルを用いて、抗癌剤と血管新生阻害剤の効果を検討した。癌細胞は高浸潤高転移性のヒトロ腔扁平上皮癌細胞株であるOSC-19細胞を使用し、ヌードマウスの口腔底もしくは舌に移植した。抗癌剤はシスプラチンを...

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Material Type: 文書・図像類
Title: 抗癌剤および血管新生阻害剤による口腔扁平上皮癌の浸潤・転移抑制効果
Author/Editor: 川尻, 秀一
Kawashiri, Shuichi
Author Heading: 川尻, 秀一
Kawashiri, Shuichi
Publication Date: 2011-05-18
Publication Date (W3CDTF): 2011-05-18
Alternative Title: Effects of anticancer drug and angiogenesis inhibitor on invasion and metastasis of oral squamous cell carcinoma
Periodical title: 平成22(2010)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2010 Fiscal Year Final Research Report
No. or year of volume/issue: 2008-2010
Volume: 2008-2010
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 抗癌剤
血管新生阻害薬
口腔扁平上皮癌
浸潤
転移
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
口腔扁平上皮癌の臨床での浸潤および転移を忠実に再現できるマウス正所性移植モデルを用いて、抗癌剤と血管新生阻害剤の効果を検討した。癌細胞は高浸潤高転移性のヒトロ腔扁平上皮癌細胞株であるOSC-19細胞を使用し、ヌードマウスの口腔底もしくは舌に移植した。抗癌剤はシスプラチンを血管新生阻害薬はトラニラストを用いて、浸潤と転移の阻止効果を調べた。その結果、腫瘍の大きさ、浸潤様式のダウングレード、リンパ節転移にそれぞれ効果を認め、臨床的にも有意義であると考えられた。
Using an orthotopic implantation mice model in which the invasion and metastasis of oral cancer can be reproduced, we investigated the inhibitory effects of anticancer agent and angiogenesis inhibitor on invasion and metastasis. A highly invasive and metastatic human oral squamous cell carcinoma cell line, OSC-19, was implanted into the tongue or oral floor of nude mice, and cisplatin or tranilast were administered to the mice after the implantation. The effects of each drug on cancer invasion and metastasiswere investigated. Tumor size and the ratio of proliferating cell nuclear antigen positive cells were significantly reduced. In the control group, the tumors showed grade 4C of mode of invasion, while in the groups treated with anticancer agent and angiogenesis inhibitor, grade 3 was observed, with an inhibitory effect on tumor invasion being observed. The rate of metastasis in the cervical lymph node was significantly decreased in the groups treated with the anticancer agent and angiogenesis inhibitor. The tumor stage progression in the metastatic lymph nodes was also inhibited. The use of anticancer agent and angiogenesis inhibitor considering these effects may be clinically very useful.
出典：研究課題「抗癌剤および血管新生阻害剤による口腔扁平上皮癌の浸潤・転移抑制効果」課題番号20592357（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20592357/20592357seika/）を加工して作成
DOI: 10.24517/00050674
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=44332&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=44332&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/search/?qm=30291371
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20592357/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20592357/20592357seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA