糖尿病臓器合併症の個別化医療にむけた抗エリスロポエチン受容体抗体の基礎臨床的検討

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Author: 和田, 隆志ほか

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Publication date: 2017-05-29

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Note (General)：: 金沢大学医薬保健研究域医学系本研究では、エリスロポエチン(EPO)とその受容体EPORを介する臓器合併症、ことに腎症の機序解明を目指し、糖尿病臓器合併症の共通進展機序である炎症、線維化に着目した。ヒト培養血管内皮細胞を用いて高糖,EPO投与有無による網羅解析とそこから得られる特異的応答分子機構を検討...

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https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293127/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26293127/26293127seika/

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Material Type: 文書・図像類
Title: 糖尿病臓器合併症の個別化医療にむけた抗エリスロポエチン受容体抗体の基礎臨床的検討
Author/Editor: 和田, 隆志
Wada, Takashi
Author Heading: 和田, 隆志
Wada, Takashi
Publication Date: 2017-05-29
Publication Date (W3CDTF): 2017-05-29
Alternative Title: Association of anti-erythropoietin receptor antibodies with organ involvement of diabetic complications
Periodical title: 平成28(2016)年度科学研究費補助金基盤研究(B) 研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 - 2017-03-31
Volume: 2014-04-01 - 2017-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 糖尿病性腎症
炎症
エリスロポエチン
エリスロポエチン受容体
自己抗体
バイオマーカー
心血管病変
バイオインフォマティクス
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
本研究では、エリスロポエチン(EPO)とその受容体EPORを介する臓器合併症、ことに腎症の機序解明を目指し、糖尿病臓器合併症の共通進展機序である炎症、線維化に着目した。ヒト培養血管内皮細胞を用いて高糖,EPO投与有無による網羅解析とそこから得られる特異的応答分子機構を検討した。新規パスウェイとしてthioredoxin interacting proteinなどインフラマゾーム活性化につながる経路を同定した。一方、EPO投与により炎症、線維化シグナル、サイトカイン発現の低下を確認した。これらより、EPOはその受容体を介して、炎症、線維化カスケードの制御を行い病態に影響を与えている可能性がある。
Diabetic nephropathy is a leading cause of end-stage kidney disease requiring renal replacement therapy in the world. Therefore, it is of importance to examine the pathogenesis of progressive organ involvement in diabetic condition. Thus far, the presence of anemia is an independent risk factor for the progression of diabetic nephropathy. In this study, we focused on the role of erythropoietin (EPO) and its receptor (EPOR), which are closely related to anemia in kidney diseases, especially in the inflammatory processes during the progression of diabetic nephropathy. Endothelial cells express inflammatory and fibrotic mediators through the activation of inflammasome in response to high glucose conditions, which could be modulated by the presence of EPO. These results suggest that EPO-EPOR axis may play a role in the pathogenesis of diabetic nephropathy.
研究課題/領域番号:26293127, 研究期間(年度):2014-04-01 - 2017-03-31
DOI: 10.24517/00050732
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=40334784
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293127/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26293127/26293127seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA