皮質視覚野損傷マウスの上丘における神経回路再編成機構

• Material Type: 文書・図像類
• Title: 皮質視覚野損傷マウスの上丘における神経回路再編成機構
• Author/Editor: 金田, 勝幸; Kaneda, Katsuyuki
• Author Heading: 金田, 勝幸; Kaneda, Katsuyuki
• Publication, Distribution, etc.: 金沢大学医薬保健研究域薬学系
• Publication Date: 2012-05-22
• Publication Date (W3CDTF): 2012-05-22
• Alternative Title: Mechanisms of reorganization in mouse superior colliculus after visual cortical lesions
• Periodical title: 平成23(2011)年度 科学研究費補助金 若手研究(B) 研究成果報告書 = 2011 Fiscal Year Final Research Report
• No. or year of volume/issue: 2010-2011
• Volume: 2010-2011
• Pages: 4p.-
• Text Language Code: jpn
• Subject Heading: 上丘; GABA作動性ニューロン; 局所神経回路; 皮質視覚野損傷; シナプス可塑性
• Target Audience: 一般
• Note (General): 中脳の上丘浅層は網膜と皮質視覚野から視覚情報入力を受けているが、皮質視覚野損傷後の上丘においてどのような可塑的変化が誘導されるのかについては不明な点が多い。そこで本研究では、この点をシナプス・細胞・回路レベルで明らかにすることを試みた。その結果、皮質損傷後の上丘ニューロンにおいて一過性の周辺抑制の増強が生じていること、また、この増強は興奮性と抑制性入力のバランスの変化により生じていることが明らかとなった。; Numerous studies have investigated the effects of lesions of the primary visual cortex(V1) on visual responses in neurons of the superficial layer of the superior colliculus(sSC), which receives visual information from both the retina and the V1. However, little is known about the changes in local circuit dynamics of the sSC after receiving V1 lesions. Here, we show that surround inhibition of sSC neurons is transiently enhanced following V1 lesions in mice and that this enhancement may be attributed to alterations in the balance between excitatory and inhibitory inputs to sSC neurons. Extracellular recordings in vivo revealed that sSC neuronal responses to large visual stimuli were transiently reduced about 1 week after visual cortical lesions compared with normal mice and that this reduction was partially recovered about 1 month after the lesions. To investigate local circuit mechanisms underlying this reduction, we performed whole-cell patch-clamp recordings from sSC neurons in slice preparations obtained from mice that had received visual cortical lesions 1 week prior to the recordings. We found cell type-dependent changes in the balance between excitation and inhibition : in non-GABAergic cells, inhibition predominated over excitation, whereas the excitation-inhibition balance did not change in GABAergic neurons. These results suggest that enhanced inhibition may be partially responsible for the reduced responses to large visual stimuli in some cells and raise the possibility that the enhanced inhibition may prevent hyperexcitability in the sSC local circuit shortly after the visual cortical lesion.; 研究課題/領域番号:22700419, 研究期間(年度):2010-2011; 出典：研究課題「皮質視覚野損傷マウスの上丘における神経回路再編成機構」課題番号22700419（KAKEN：科学研究費助成事業データベース（国立情報学研究所）） （https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22700419/22700419seika/）を加工して作成
• DOI: 10.24517/00050929
• Access Restrictions: 限定公開
• Related Material: https://kaken.nii.ac.jp/search/?qm=30421366; https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700419/; https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22700419/22700419seika/
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA