肝発癌を促進する腸内細菌叢の同定

Material type: 文書・図像類

Author: 飯田, 宗穂ほか

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Publication date: 2015-05-28

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Note (General)：: 金沢大学医薬保健研究域医学系Ｃ型慢性肝炎由来肝細胞癌患者(HCC)8名、非担癌Ｃ型慢性肝炎患者(CLD)8名、健常者(HD)６名の便中DNAのシーケンシングを行った。HD ５人とCLD ３人が近くクラスタリングされ、HCC8人を含む残りが近くクラスタリングされ、肝癌患者は健常者と異なる細菌叢を持つこ...

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https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25893081/

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Material Type: 文書・図像類
Title: 肝発癌を促進する腸内細菌叢の同定
Author/Editor: 飯田, 宗穂
Iida, Noriho
Author Heading: 飯田, 宗穂
Iida, Noriho
Publication Date: 2015-05-28
Publication Date (W3CDTF): 2015-05-28
Alternative Title: Impact of gut microbiota on promotion of liver carcinogenesis
Periodical title: 平成26(2014)年度科学研究費補助金研究活動スタート支援研究成果報告書 = 2014 Fiscal Year Final Research Report
No. or year of volume/issue: 2013-08-30 - 2015-03-31
Volume: 2013-08-30 - 2015-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 肝癌
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
Ｃ型慢性肝炎由来肝細胞癌患者(HCC)8名、非担癌Ｃ型慢性肝炎患者(CLD)8名、健常者(HD)６名の便中DNAのシーケンシングを行った。HD ５人とCLD ３人が近くクラスタリングされ、HCC8人を含む残りが近くクラスタリングされ、肝癌患者は健常者と異なる細菌叢を持つことが示唆された。肝癌患者便を移植したマウスでは肝発癌が67%であったのに対し、健常者便移植マウスでの肝発癌率は0%であった。
Sequencing with fecal DNA harvested from hepatocellular carcinoma (HCC) patients, chronic liver disease (CLD) patients and healthy donors (HD) reveals that the microbiota of the HCC patients was differently clustered from HD microbiota. Liver carcinogenesis was observed in 67 % of mice transplanted with feces of HCC patients, but no carcinogenesis was seen in the mice transplanted with HD feces.
研究課題/領域番号:25893081, 研究期間(年度):2013-08-30 - 2015-03-31
DOI: 10.24517/00050955
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=40705604
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25893081/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25893081/25893081seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA