蛍光イメージングを用いた骨軟部腫瘍の進展機序解明と治療戦略

Material type: 文書・図像類

Author: 土屋, 弘行ほか

Publisher: 金沢大学医薬保健研究域医学系

Publication date: 2014-06-12

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Note (General)：: 金沢大学医薬保健研究域医学系蛍光標識骨肉腫細胞をin vivoでの継代で転移能の異なる細胞を作成し転移能が上昇するにつれてPAI-1・u-PAの濃度が上昇していた。カフェインの抗腫瘍効果はPTEN/Akt経路に加え、NF-κB、ERKを抑制することを明らかにした。Fluorescent Ubiqui...

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Material Type: 文書・図像類
Title: 蛍光イメージングを用いた骨軟部腫瘍の進展機序解明と治療戦略
Author/Editor: 土屋, 弘行
Tsuchiya, Hiroyuki
Author Heading: 土屋, 弘行
Tsuchiya, Hiroyuki
Publication, Distribution, etc.: 金沢大学医薬保健研究域医学系
Publication Date: 2014-06-12
Publication Date (W3CDTF): 2014-06-12
Alternative Title: Treatment strategy and analysis of progression mechanism of musculoskeletal tumors using fluorescent imaging
Periodical title: 平成25(2013)年度科学研究費補助金基盤研究(B) 研究成果報告書 = 2013 Fiscal Year Final Research Report
No. or year of volume/issue: 2011-04-01 - 2014-03-31
Volume: 2011-04-01 - 2014-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 骨・軟部腫瘍学
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
蛍光標識骨肉腫細胞をin vivoでの継代で転移能の異なる細胞を作成し転移能が上昇するにつれてPAI-1・u-PAの濃度が上昇していた。カフェインの抗腫瘍効果はPTEN/Akt経路に加え、NF-κB、ERKを抑制することを明らかにした。Fluorescent Ubiquitination-based Cell Cycle Indicatorを用いて、カフェインが細胞周期の停止を阻害し抗癌剤を増強させることが分かった。テオブロミンの作用について検討し、抗腫瘍作用があることが分かった。骨軟部悪性腫瘍の蛍光イメージング目的に、ICGを用いて骨軟部腫瘍患者で施行し手術のナビゲーションとなり得た。
Fluorescent labeled osteosarcoma cell line was transplanted in nude mice and harvested in lung metastasis to obtain higher metastatic cell line. The more metastatic potential, the more PAI -1 and u-PA levels increased. We previously reported that caffeine-assisted chemotherapy. We found caffeine affects tumor cells through various pathways, such as PTEN, AKT, NF-kB, and ERK activities. Modulation of cisplatinum efficacy induced by caffeine was visualized at the subcellular level by fluorescent ubiquitination-based cell cycle indicator in the nucleus. Caffeine overcame the cell-cycle arrest induced by cisplatinum, thereby increasing its efficacy. Theobromine, a caffeine derivative, was investigated as a new anti-cancer effect. It elevates intracellular cAMP levels and inhibits cell proliferation. Surgical navigation for bone and soft tissue tumor in mouse and human was also performed using ICG and near-infrared fluorescent imaging.
研究課題/領域番号:23390360, 研究期間(年度):2011-04-01 - 2014-03-31
出典：研究課題「蛍光イメージングを用いた骨軟部腫瘍の進展機序解明と治療戦略」課題番号23390360（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390360/23390360seika/）を加工して作成
DOI: 10.24517/00051055
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=44714&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=44714&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/search/?qm=40227434
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390360/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390360/23390360seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA