幹細胞ニッチに着目した軟骨膜片移植による長期形態維持性耳介軟骨再生法の開発

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Author: 小室, 明人ほか

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Publication date: 2016-05-25

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Note (General)：: 金沢大学附属病院耳介軟骨再生の課題である長期形態維持性を改善するため、近年軟骨膜に存在することが判明した組織幹細胞とその保持機構に着目した。家兎耳介の研究を計画したが、先に自らの家兎肋軟骨膜研究で、軟骨新生の前に軟骨膜内に血管新生が生じることが明らかになり、肋軟骨モデルで、血管新生阻害剤を持続投与し...

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https://kaken.nii.ac.jp/search/?qm=80387365

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670780/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670780/26670780seika/

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Material Type: 文書・図像類
Title: 幹細胞ニッチに着目した軟骨膜片移植による長期形態維持性耳介軟骨再生法の開発
Author/Editor: 小室, 明人
Komuro, Akito
Author Heading: 小室, 明人
Komuro, Akito
Publication Date: 2016-05-25
Publication Date (W3CDTF): 2016-05-25
Alternative Title: Development of the method which focus its attention on a stem-cell niche, for regenerating long-term from-retaing auricular cartilage by the piece transplantation of a perichondrium
Periodical title: 平成27(2015)年度科学研究費補助金挑戦的萌芽研究研究成果報告書 = 2015 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 - 2016-03-31
Volume: 2014-04-01 - 2016-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 軟骨膜組織幹細胞・前駆細胞
幹細胞ニッチ
血管新生
Target Audience: 一般
Note (General): 金沢大学附属病院
耳介軟骨再生の課題である長期形態維持性を改善するため、近年軟骨膜に存在することが判明した組織幹細胞とその保持機構に着目した。家兎耳介の研究を計画したが、先に自らの家兎肋軟骨膜研究で、軟骨新生の前に軟骨膜内に血管新生が生じることが明らかになり、肋軟骨モデルで、血管新生阻害剤を持続投与し、血管新生の阻害と軟骨新生との関連について調べた。血管新生阻害剤により、軟骨膜内の新生血管数が減少し、その後の新生軟骨量も有意に抑制された。軟骨膜血管新生と新生軟骨の増殖・分化に相関を認めたことから、軟骨膜内での血管新生が軟骨膜前駆細胞/ 組織幹の保持機構に作用し、軟骨新生対するトリガーになることが示唆された。
We planned the study using the rabbit auricular cartilage paying our attention to stem cells and its maintenance mechanism to improve the long-term form maintainability that have been a problem of the auricular cartilage reproduction. But in own study for the rabbit rib perichondrium, it was found earlier that neovascularization occurred in a perichondrium before chondrogenesis.So we examined an association between angiogenetic inhibition and the chondrogenesis in this model. By administration of neovascularization inhibitor, the neovascularity in the perichondrium decreased and significantly the quantity of subsequent chondrogensis was inhibited. Because the growth and differentiation of the perichondrium cells thought to be the stem cells origin showed a correlation of the chondrogenesis, the neovascularization acted for the maintenance mechanism of the perichondrium stem/progenitor cells. It was suggested that the neovascularization in the perichondrium triggered the chondrogenesis.
研究課題/領域番号:26670780, 研究期間(年度):2014-04-01 - 2016-03-31
DOI: 10.24517/00051407
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=80387365
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670780/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670780/26670780seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA