心不全及び背景疾患が脂肪由来間葉系幹細胞の再生誘導効率に与える影響についての検討

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Author: 高島, 伸一郎ほか

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Publication date: 2016-05-31

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Note (General)：: 金沢大学附属病院心血管疾患に対する待機的手術を受けた患者17例を対象に、手術時に得た余剰皮下脂肪組織1-2gを酵素処理し、フローサイトメトリー法にて皮下脂肪組織由来間葉系幹細胞のプロファイリングを施行し、背景疾患との関連を検討した。17例の平均年齢は72歳(男性は12例)、背景疾患の内訳は高血圧94...

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Material Type: 文書・図像類
Title: 心不全及び背景疾患が脂肪由来間葉系幹細胞の再生誘導効率に与える影響についての検討
Author/Editor: 高島, 伸一郎
Takashima, Shinichiro
Author Heading: 高島, 伸一郎
Takashima, Shinichiro
Publication Date: 2016-05-31
Publication Date (W3CDTF): 2016-05-31
Alternative Title: Impact of clinical characteristics on the yield of therapeutic adipose-derived mesenchymal stem cells in a cardiovascular disease
Periodical title: 平成27(2015)年度科学研究費補助金若手研究(B) 研究成果報告書 = 2015 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 - 2016-03-31
Volume: 2014-04-01 - 2016-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 間葉系幹細胞
皮下脂肪
心血管疾患
Target Audience: 一般
Note (General): 金沢大学附属病院
心血管疾患に対する待機的手術を受けた患者17例を対象に、手術時に得た余剰皮下脂肪組織1-2gを酵素処理し、フローサイトメトリー法にて皮下脂肪組織由来間葉系幹細胞のプロファイリングを施行し、背景疾患との関連を検討した。17例の平均年齢は72歳(男性は12例)、背景疾患の内訳は高血圧94%、脂質異常77%、糖尿病59%であった。左室駆出分画が40%未満の低心機能患者は24％であった。注目すべきことに再生治療効果が高いとされるCD271陽性細胞の含有比率は症例ごとに特に大きなばらつきを認め、個々の背景が皮下脂肪組織由来間葉系幹細胞プロファイリングに影響し、治療効果に影響を及ぼす可能性が示された。
The problem of autologous stem cell therapy for cardiovascular disease is that a large variability of therapeutic effects among patients. We conducted a clinical study to examine the variation in yield of therapeutic stem cells in subcutaneous adipose tissue (SAT) among patients. From 17 patients who underwent cardiac surgery, 1-2g of SAT was obtained and digested with collagenase to isolate stromal vascular fraction (SVF). Mesenchymal stem cell markers in SVF were analyzed by flow cytometry. The frequency of the patients with hypertension, dyslipidemia and diabetes was 94%, 77% and 59%, respectively. Interestingly, the content of CD271-positive cells that is reported as a specific marker of therapeutic stem cells largely varied among patients and was associated with the specific clinical feature. These indicated that the clinical background would impact on yield of therapeutic stem cells in SAT and efficacy of cardiac stem cell therapy.
研究課題/領域番号:26860549, 研究期間(年度):2014-04-01 - 2016-03-31
DOI: 10.24517/00051408
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=60547165
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860549/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26860549/26860549seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA