大動脈弁狭窄症における心筋内微小循環の評価と臨床応用

Material type: 文書・図像類

Author: 坂田, 憲治ほか

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Publication date: 2017-06-08

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Note (General)：: 金沢大学附属病院循環器内科一回拍出量の低下した予後不良の大動脈弁狭窄症例において、温度センサー付きPressure Wire による術前の微小血管抵抗指標（IMR）、微小血管抵抗予備能比（RRR）が術後の左心機能回復に影響するか検討した。術後6ヵ月での一回拍出量の改善群7名と改善無群14名の間では、...

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Material Type: 文書・図像類
Title: 大動脈弁狭窄症における心筋内微小循環の評価と臨床応用
Author/Editor: 坂田, 憲治
Sakata, Kenji
Author Heading: 坂田, 憲治
Sakata, Kenji
Publication Date: 2017-06-08
Publication Date (W3CDTF): 2017-06-08
Alternative Title: Impact of vasodilatory capacity of the coronary microcirculation on improvement of left ventricular function after valve replacement in patients with aortic stenosis
Periodical title: 平成28(2016)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 - 2017-03-31
Volume: 2014-04-01 - 2017-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 大動脈弁狭窄症
心筋内微小循環
Target Audience: 一般
Note (General): 金沢大学附属病院循環器内科
一回拍出量の低下した予後不良の大動脈弁狭窄症例において、温度センサー付きPressure Wire による術前の微小血管抵抗指標（IMR）、微小血管抵抗予備能比（RRR）が術後の左心機能回復に影響するか検討した。術後6ヵ月での一回拍出量の改善群7名と改善無群14名の間では、術前のIMR、RRRに差を認めなかった。術前で一回拍出量の保たれている群では、術後一回拍出量の改善した群が改善無群と比べ有意にIMRが高かった。術前一回拍出量の低下した群では、術前の各指標に差を認めなかった。術後一回心拍出量の改善した症例と改善しない症例で術前の心筋微小循環障害や心筋微小血管拡張予備能に差異を認めなかった。
The purpose of this study was to investigate the vasodilatory capacity of the coronary microcirculation on improvement of left ventricular function after valve replacement in patients with low-flow aortic stenosis. The index of microvascular resistance (IMR) and resistive reserve ratio (RRR) before valve replacement were not significantly different between the groups with and without improvement of % changes in stroke volume index (SVI) six month after valve replacement. In the setting of normal-flow aortic stenosis before surgery, IMR was significantly higher in the group with improvement of SVI than those without. In contrast, in the setting of low-flow aortic stenosis before surgery, IMR and RRR were not significantly different between the two groups. In conclusion, the indices of vasodilatory capacity of the coronary microcirculation before surgery were not different between groups with and without improvement of left ventricular function.
研究課題/領域番号:26461058, 研究期間(年度):2014-04-01 - 2017-03-31
DOI: 10.24517/00051514
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=45175&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=45175&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/search/?qm=20456411
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461058/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461058/26461058seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA