抗microRNA122療法を基軸とした新規抗C型肝炎ウイルス治療法の開発

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Author: 島上, 哲朗ほか

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Publication date: 2015-05-26

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Note (General)：: 金沢大学附属病院地域医療教育センター今後C型慢性肝炎治療はDirect-Acting Antiviral Agents (DAA)耐性ウイルスが問題となる．今回肝特異的に発現するmicroRNA-122 (miR-122)を標的とした抗miR-122療法とDAA併用療法の有用性を検討した．その結果，...

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https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790687/

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Material Type: 文書・図像類
Title: 抗microRNA122療法を基軸とした新規抗C型肝炎ウイルス治療法の開発
Author/Editor: 島上, 哲朗
Shimakami, Tetsuro
Author Heading: 島上, 哲朗
Shimakami, Tetsuro
Publication Date: 2015-05-26
Publication Date (W3CDTF): 2015-05-26
Alternative Title: Clarification of Mechanism of Anti-microRNA-122 Therapy for Hepatitis C Virus Infection
Periodical title: 平成26(2014)年度科学研究費補助金若手研究(B) 研究成果報告書 = 2014 Fiscal Year Final Research Report
No. or year of volume/issue: 2012-04-01 - 2015-03-31
Volume: 2012-04-01 - 2015-03-31
Pages: 5p.-
Text Language Code: jpn
Subject Heading: C型肝炎ウイルス
microRNA-122
C型慢性肝炎
抗ウイルス療法
Target Audience: 一般
Note (General): 金沢大学附属病院地域医療教育センター
今後C型慢性肝炎治療はDirect-Acting Antiviral Agents (DAA)耐性ウイルスが問題となる．今回肝特異的に発現するmicroRNA-122 (miR-122)を標的とした抗miR-122療法とDAA併用療法の有用性を検討した．その結果，DAAと抗miR-122療法の併用により相乗的な抗ウイルス効果を示し，DAA耐性ウイルスにDAAと抗miR-122療法を併用することでDAA耐性が改善し, DAAと抗miR-122療法併用によりDAA耐性ウイルスの出現を抑制した．これらの結果から DAAと抗miR-122療法併用は，DAA耐性ウイルスを抑制しうる点で有用と考えられた．
The emergence of Direct-Acting Antiviral Agents (DAA)-resistant virus could be a serious problem for the treatment of chronic hepatitis C patients. We examined the efficiency of the combination therapy with DAA and anti-miR-122 therapy, which is targeting liver-specific miRNA, miR-122. We demonstrated that the combination therapy (1) shows synergistic antiviral effect, (2) alleviates the drug resistance of DAA-resistance viruses, and (3)completely inhibits the emergence of DAA-resistance virus. These results indicate that anti-miR-122 therapy is quite useful in terms of inhibiting the emergence of DAA-resistance virus when it is combined with DAA.
研究課題/領域番号:24790687, 研究期間(年度):2012-04-01 - 2015-03-31
DOI: 10.24517/00051548
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=50436820
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790687/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24790687/24790687seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA