緑内障性視神経障害進行の活動部位仮説の立証と乳頭出血、予後予測に関する研究

Material type: 文書・図像類

Author: 杉山, 和久ほか

Publisher: 金沢大学医薬保健研究域医学系

Publication date: 2014-05-26

Material Format: Digital

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Note (General)：: 網膜神経線維欠損（NFLD）を明瞭に確認できる正常眼圧緑内障（NTG）を対象に，経時的に NFLD角度を測定し，拡大群と不変群の長期経過の差異を， DHの出現，視野障害の進行から解析した。NFLD拡大群の方が有意にDHの頻度が高く、視野障害の進行を認めた。DHはそのほとんどがNFLDの境界近傍に生じ...

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Material Type: 文書・図像類
Title: 緑内障性視神経障害進行の活動部位仮説の立証と乳頭出血、予後予測に関する研究
Author/Editor: 杉山, 和久
Sugiyama, Kazuhisa
Author Heading: 杉山, 和久
Sugiyama, Kazuhisa
Publication, Distribution, etc.: 金沢大学医薬保健研究域医学系
Publication Date: 2014-05-26
Publication Date (W3CDTF): 2014-05-26
Alternative Title: Active site heypothesis for progression of glaucomatous optic neuropathy and optic disc hemorrhage, and research for prediction of progression
Periodical title: 平成25(2013)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2013 Fiscal Year Final Research Report
No. or year of volume/issue: 2010-04-01 - 2014-03-31
Volume: 2010-04-01 - 2014-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 乳頭出血
緑内障性視神経症
ＯＣＴ
網膜神経線維層欠損
正常眼圧緑内障
危険因子
Target Audience: 一般
Note (General): 網膜神経線維欠損（NFLD）を明瞭に確認できる正常眼圧緑内障（NTG）を対象に，経時的に NFLD角度を測定し，拡大群と不変群の長期経過の差異を， DHの出現，視野障害の進行から解析した。NFLD拡大群の方が有意にDHの頻度が高く、視野障害の進行を認めた。DHはそのほとんどがNFLDの境界近傍に生じ，NFLDはDHをきたした方向に拡大し，しかも黄斑側に拡大しやすい。DHはNFLDが拡大する際に毛細血管網が破綻して境界線に沿って出現する可能性が高い。Rim notchとそれに続くNFLDの境界線が早期緑内障での進行のActive siteと考えられる。
To elucidate the pathogenesis of glaucoma progression, we measured retinal nerve fiber layer defects (RNFLD) angles and divided normal-tension glaucoma (NTG) cases into 2 groups, enlarged RNFLD and stable RNFLD. Disc hemorrhages were found significantly more frequent in the enlarged group than in the stable group. RNFLD enlarged in the direction of disc hemorrhage in over 80% of eyes. In majority of eyes of the enlarged group, the enlargement of RNFLD was toward the fovea. The enlargement of RNFLD in NTG was closely associated with disc hemorrhage occurrence and the deterioration of visual field.
研究課題/領域番号:22591936, 研究期間(年度):2010-04-01 - 2014-03-31
出典：研究課題「緑内障性視神経障害進行の活動部位仮説の立証と乳頭出血、予後予測に関する研究」課題番号22591936（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591936/22591936seika/）を加工して作成
DOI: 10.24517/00051624
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=80179168
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591936/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22591936/22591936seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA