標的タンパク発現プロファイルに基づく新規膠芽腫分類の試み

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Author: 中田, 光俊ほか

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Publication date: 2016-09-15

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Note (General)：: 金沢大学医薬保健研究域医学系本研究ではタンパク質の絶対定量値を取得できる独自のプロテオミクス技術を用いた新規の膠芽腫サブタイプ分類の樹立を試みた。相互排他的な発現パターンを示すEGFR, ERBB2, PDGFRαに着目し、初発膠芽腫をEGFR群25例、PDGFRα群11例、ERBB2群7例に分類し...

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https://kaken.nii.ac.jp/search/?qm=20334774

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670638/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670638/26670638seika/

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Material Type: 文書・図像類
Title: 標的タンパク発現プロファイルに基づく新規膠芽腫分類の試み
Author/Editor: 中田, 光俊
Nakada, Mitsutoshi
Author Heading: 中田, 光俊
Nakada, Mitsutoshi
Publication Date: 2016-09-15
Publication Date (W3CDTF): 2016-09-15
Alternative Title: Molecular subclassification of glioblastoma based on the absolute quantitative proteomics
Periodical title: 平成27(2015)年度科学研究費補助金挑戦的萌芽研究研究成果報告書 = 2015 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 - 2016-03-31
Volume: 2014-04-01 - 2016-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 膠芽腫
プロテオミクス
チロシンキナーゼ
分類
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
本研究ではタンパク質の絶対定量値を取得できる独自のプロテオミクス技術を用いた新規の膠芽腫サブタイプ分類の樹立を試みた。相互排他的な発現パターンを示すEGFR, ERBB2, PDGFRαに着目し、初発膠芽腫をEGFR群25例、PDGFRα群11例、ERBB2群7例に分類した。PFS中央値はそれぞれ8.3, 12.8, 37ヶ月で、OS中央値はそれぞれ16.1, 17.9, 25.7ヶ月であり、ERBB2群でPFS, OSが延長する傾向があった。以上の結果から、絶対定量プロテオミクスによるチロシンキナーゼの絶対発現量に基づいた膠芽腫のサブタイプ分類が可能であると考えられた。
The purpose of this study is to attempt to classify GBM subtypes based on the molecular profile determined by absolute quantitative proteomics and to investigate its clinical significance. GBMs in our study harbored mutually exclusive dominant expression of three RTKs; EGFR, PDGFRα and ERBB2. Therefore, we propose a subclassification of GBM with respect to the dominant expression of these proteins; EGFR (n=25), PDGFRα (n=11) and ERBB2 (n=7). PFS and OS tended to be longer in ERBB2 group in comparison with EGFR and PDGFRα group. Molecular subclassification of GBM based on the absolute quantitative proteomics reflects the clinical behavior and might have clinical significance.
研究課題/領域番号:26670638, 研究期間(年度):2014-04-01 - 2016-03-31
DOI: 10.24517/00051721
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=20334774
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670638/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26670638/26670638seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA