放射線照射が硬膜に及ぼす影響: 照射後髄液漏の原因究明

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Author: 村上, 英樹ほか

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Publication date: 2017-04-13

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Note (General)：: 金沢大学医薬保健研究域医学系本研究により、マウス脊椎への放射線照射後に硬膜外腔の繊維化（fibrosis）が誘発されることが確認され、fibrosis発生の中心的役割を果たすとされるサイトカイン、TGF-β1の過剰発現も認められた。また、髄膜の透過性に強く関与するくも膜バリア細胞層が放射線照射後に菲...

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Material Type: 文書・図像類
Title: 放射線照射が硬膜に及ぼす影響: 照射後髄液漏の原因究明
Author/Editor: 村上, 英樹
Murakami, Hideki
Author Heading: 村上, 英樹
Murakami, Hideki
Publication Date: 2017-04-13
Publication Date (W3CDTF): 2017-04-13
Alternative Title: Effects of Radiation on Spinal Dura Mater and Surrounding Tissue in Mice
Periodical title: 平成28(2016)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 - 2017-03-31
Volume: 2014-04-01 - 2017-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 放射線障害
硬膜外fibrosis
硬膜損傷
髄液漏
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
本研究により、マウス脊椎への放射線照射後に硬膜外腔の繊維化（fibrosis）が誘発されることが確認され、fibrosis発生の中心的役割を果たすとされるサイトカイン、TGF-β1の過剰発現も認められた。また、髄膜の透過性に強く関与するくも膜バリア細胞層が放射線照射後に菲薄化することが確認された。これらの放射線障害は、照射後の脊椎手術における合併症発生（硬膜損傷や髄液漏）の一因になり得る。
This study confirms that epidural fibrosis is induced in the late stages after high-dose irradiation in mice, and that overexpression of TGF-β1 occurs in a manner similar to radiation-induced fibrosis in other tissue. Additionally, thinning of the ABC was observed in the late stages after irradiation. Thus, consideration should be given to the possibility that these phenomena can occur as radiation-induced injuries of the spine.
研究課題/領域番号:26462233, 研究期間(年度):2014-04-01 - 2017-03-31
DOI: 10.24517/00051731
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=70334779
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462233/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26462233/26462233seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA