軸索ガイダンス分子draxinが担う視床皮質軸索投射機構の解明

Material type: 文書・図像類

Author: 新明, 洋平ほか

Publisher: 金沢大学医薬保健研究域医学系 / 熊本大学

Publication date: 2014-06-03

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Note (General)：: draxinはサブプレート神経を含む大脳新皮質に強く、大脳腹側部と視床に弱く発現する。大脳新皮質に発現するdraxinが視床皮質軸索投射に重要であるかを検証するために、レスキュー実験を行った。pCAGGSプロモーター下にloxpを両端に持つβ-geoとさらに下流にdraxin-IRES-eGFPを持...

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Material Type: 文書・図像類
Title: 軸索ガイダンス分子draxinが担う視床皮質軸索投射機構の解明
Author/Editor: 新明, 洋平
Shinmyo, Yohei
Author Heading: 新明, 洋平
Shinmyo, Yohei
Publication, Distribution, etc.: 金沢大学医薬保健研究域医学系 / 熊本大学
Publication Date: 2014-06-03
Publication Date (W3CDTF): 2014-06-03
Alternative Title: Draxin roles in thalamocortical projections
Periodical title: 平成25(2013)年度科学研究費補助金若手研究(A) 研究成果報告書 = 2013 Fiscal Year Final Research Report
No. or year of volume/issue: 2011-04-01 - 2014-03-31
Volume: 2011-04-01 - 2014-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 軸索ガイダンス
視床皮質軸索投射
Target Audience: 一般
Note (General): draxinはサブプレート神経を含む大脳新皮質に強く、大脳腹側部と視床に弱く発現する。大脳新皮質に発現するdraxinが視床皮質軸索投射に重要であるかを検証するために、レスキュー実験を行った。pCAGGSプロモーター下にloxpを両端に持つβ-geoとさらに下流にdraxin-IRES-eGFPを持つトランスジェニックマウスを作成した。このマウスを用いてdraxinノックアウトマウスにおいて大脳新皮質特異的にdraxinの発現を誘導した結果、多くの視床皮質軸索が大脳新皮質に向かって投射する事が分かった。この結果から、サブプレートを含む大脳新皮質に発現するdraxinの重要性が示唆された。
In this study, we have focused on Draxin functions in thalamocortical projections. It has long been recognized that neocortical pioneer axons from subplate neurons are essential for the guidance of thalamocortical projections. Draxin is strongly expressed in early-born cortical neurons, including subplate and Cajal-Retzius cells, and weakly expressed in the ventral telencephalon and dorsal thalamus. Draxin deficient mice showed severe defects in thalamocortical projections. Thalamic axons showed a pathfinding error in the internal capsule region at embryonic day 14.5, when cortical axon pathfinding still appeared normal.This suggests that draxin has direct functions in thalamocortical projections. Furthermore, the thalamocortical phenotype in draxin-/- mice is sufficiently rescued by transgenic expression of draxin in the neocortex. These results suggest that draxin from neocortical pioneer neurons is required for the guidance of thalamocortical projections.
研究課題/領域番号:23680036, 研究期間(年度):2011-04-01 - 2014-03-31
出典：研究課題「軸索ガイダンス分子draxinが担う視床皮質軸索投射機構の解明」課題番号23680036（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23680036/23680036seika/）を加工して作成
DOI: 10.24517/00051776
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=00418831
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23680036/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23680036/23680036seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA