小児の抗HIV治療による免疫状態の改善と至適マーカーの同定

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Author: 畢, 袖晴ほか

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Publication date: 2017-05-29

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Note (General)：: 金沢大学医薬保健研究域医学系本研究では、ベトナムのヒト免疫不全ウイルス（HIV）感染小児において、抗HIV療法(ART)が小児の免疫活性化、Th1/Th2/Th17/Tregのバランスに及ぼす影響を横断的並びに経時的に調べた。横断的調査では、ART導入後、CD4細胞数、Th2/Th17/Treg細胞...

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Material Type: 文書・図像類
Title: 小児の抗HIV治療による免疫状態の改善と至適マーカーの同定
Author/Editor: 畢, 袖晴
Bi, Xiuqiong
Author Heading: 畢, 袖晴
Bi, Xiuqiong
Publication Date: 2017-05-29
Publication Date (W3CDTF): 2017-05-29
Alternative Title: Immune improvement after anti-retroviral therapy (ART) initiation and identification of appropriate markers for ART monitoring in HIV-infected children
Periodical title: 平成28(2016)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 - 2017-03-31
Volume: 2014-04-01 - 2017-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: HIV
抗HIV療法
免疫状態
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
本研究では、ベトナムのヒト免疫不全ウイルス（HIV）感染小児において、抗HIV療法(ART)が小児の免疫活性化、Th1/Th2/Th17/Tregのバランスに及ぼす影響を横断的並びに経時的に調べた。横断的調査では、ART導入後、CD4細胞数、Th2/Th17/Treg細胞数、およびCD4/CD8比は徐々に上昇し、正常化までに4.8-8.3年を要したが、Th17細胞数とCD8細胞の活性化状態は1年以内に正常化した。経時的調査でARTによる早期（１年以内）のTh1細胞数とCD8細胞活性化状態の正常化が確認された。また、CD4/CD8比はARTモニタリングに有用なマーカーであることが示唆された。
This study aimed to investigate the impact of ART on the immune status of HIV-infected Vietnamese children. The peripheral CD4 cells, their subsets Th1/Th2/Th17/Treg, and CD8 cell activation were analyzed cross-sectionally and longitudinally.Cross-sectional study revealed that after ART initiation, the total CD4 cell and Th2/Th17/Treg subset counts and the CD4/CD8 ratio gradually increased, with estimated ART periods of normalization being 4.8-8.3 years, whereas Th1 counts and the CD8 cell activation status normalized within 1 year of ART. Longitudinal study confirmed the rapid Th1 recovery and early CD8 cell activation normalization after ART initiation. The CD4/CD8 ratio could be an additional marker for ART monitoring.
研究課題/領域番号:26461572, 研究期間(年度):2014-04-01 - 2017-03-31
DOI: 10.24517/00051811
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=50565413
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461572/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461572/26461572seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA