脳脊髄液の性状が脳動脈壁組織脆弱性に与える影響についての検討

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Author: 塚, 正彦ほか

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Publication date: 2017-06-11

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Note (General)：: 金沢大学医薬保健研究域医学系法医解剖事例における小型の未破裂脳動脈瘤の頻度と分布を、脳脊髄液(CSF)の生化学的性状と併せて解析した結果、CSF中のゼラチナーゼ(galatinase A及びgalatinase B)活性が脳動脈瘤早期病変の鋭敏な指標となりうる（p<0.001）事が分かった。また、C...

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Material Type: 文書・図像類
Title: 脳脊髄液の性状が脳動脈壁組織脆弱性に与える影響についての検討
Author/Editor: 塚, 正彦
Zuka, Masahiko
Author Heading: 塚, 正彦
Zuka, Masahiko
Publication Date: 2017-06-11
Publication Date (W3CDTF): 2017-06-11
Alternative Title: Analysis of vascular tissue fragility of cerebral arteries affected by cerebrospinal fluid
Periodical title: 平成28(2016)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 - 2017-03-31
Volume: 2014-04-01 - 2017-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 脳動脈瘤
プロテアーゼ
脳脊髄液
カルシウム
α-Klotho蛋白
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
法医解剖事例における小型の未破裂脳動脈瘤の頻度と分布を、脳脊髄液(CSF)の生化学的性状と併せて解析した結果、CSF中のゼラチナーゼ(galatinase A及びgalatinase B)活性が脳動脈瘤早期病変の鋭敏な指標となりうる（p<0.001）事が分かった。また、CSF中のゼラチン分解活性は、局所におけるCa調節を司るα-Klotho蛋白の部位別測定値（脳槽CSF、側脳室CSF及び血清中に各々542～5,461 pg/mL、2,758～5,971 pg/mL及び600～5,556 pg/mL）とも連動しており、病理組織学的解析と併せてCa濃度依存性の脳動脈瘤進展のメカニズムが示唆された。
The frequency and distribution of unruptured cerebral aneurysms of minimal size in forensic autopsy cases were analyzed, measuring the activities of galatinases in cerebrospinal fluid(CSF). The results showed that gelatinolytic activities of CSF generated from gelatinase A and B can serve as good markers of early-stage cerebral aneurysm（p<0.001）. Moreover the gelatinolytic activities of CSF demonstrated parallels with the concentration of α-Klotho protein by which Ca deposition is controlled locally in the body. Therefore, combined with the microscopic findings, these Ca-dependent biochemical values of CSF can help to predict the development of cerebral aneurysms.
研究課題/領域番号:26460874, 研究期間(年度):2014-04-01 - 2017-03-31
DOI: 10.24517/00051816
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=45479&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=45479&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/search/?qm=00272956
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460874/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26460874/26460874seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA