超臨界二酸化炭素中の医薬品有機化合物の結晶多形転移現象のメカニズム解明とその制御

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Author: 内田, 博久ほか

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Publication date: 2017-06-28

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Note (General)：: 金沢大学理工研究域フロンティア工学系本研究は，「医薬品有機化合物を超臨界二酸化炭素に接触・溶解させた後に減圧する手法」による結晶多形転移メカニズムの解明を目的とする。具体的には，超臨界二酸化炭素＋テオフィリン混合系に対する種々の操作因子（超臨界二酸化炭素の温度と圧力，二酸化炭素の減圧速度および薬物の...

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https://kaken.nii.ac.jp/search/?qm=70313294

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14201/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K14201/15K14201seika/

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Material Type: 文書・図像類
Title: 超臨界二酸化炭素中の医薬品有機化合物の結晶多形転移現象のメカニズム解明とその制御
Author/Editor: 内田, 博久
Uchida, Hirohisa
Author Heading: 内田, 博久
Uchida, Hirohisa
Publication Date: 2017-06-28
Publication Date (W3CDTF): 2017-06-28
Alternative Title: Mechanism elucidation and control of crystal polymorphic phase transitions of drugs in supercritical carbon dioxide
Periodical title: 平成28(2016)年度科学研究費補助金挑戦的萌芽研究研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2015-04-01 - 2017-03-31
Volume: 2015-04-01 - 2017-03-31
Pages: 5p.-
Text Language Code: jpn
Subject Heading: 結晶多形
多形転移
超臨界二酸化炭素
薬物
テオフィリン
Target Audience: 一般
Note (General): 金沢大学理工研究域フロンティア工学系
本研究は，「医薬品有機化合物を超臨界二酸化炭素に接触・溶解させた後に減圧する手法」による結晶多形転移メカニズムの解明を目的とする。具体的には，超臨界二酸化炭素＋テオフィリン混合系に対する種々の操作因子（超臨界二酸化炭素の温度と圧力，二酸化炭素の減圧速度および薬物の乾燥状態）の影響を検討した。温度，圧力および減圧速度を変化させた場合，全ての条件で結晶多形転移が生じた。次に，テオフィリンを十分に乾燥した後に超臨界二酸化炭素処理を行ったところ，結晶多形転移は起こらなかった。これより，超臨界二酸化炭素中のテオフィリンの結晶多形転移は，テオフィリンに含まれる水分が影響していることがわかった。
This work aims to elucidate the mechanism of a polymorphic phase transition of drugs treated by a new technique of decompressing carbon dioxide after contacting the drugs to supercritical carbon dioxide. In this work, we examined the effects of several operating parameters such as temperatures and pressures of supercritical carbon dioxide, decompression rates of carbon dioxide from supercritical conditions to an atmospheric pressure condition, and drying states of drugs: moisture in the drugs on a polymorphic phase transition of theophylline in supercritical carbon dioxide. In case of changing temperatures, pressures, and decompression rates, a new polymorphic phase transition was obtained. When theophylline samples after fully drying were contacted to supercritical carbon dioxide, polymorphic phase transitions were not obtained. This result showed that the moisture in theophylline would affect the polymorphic phase transitions of theophylline treated by the present technique.
研究課題/領域番号:15K14201, 研究期間(年度):2015-04-01 - 2017-03-31
DOI: 10.24517/00052365
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=70313294
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14201/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K14201/15K14201seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA