超臨界溶体急速膨張法を利用した医薬用有機ナノ粒子設計技術の実用化基盤の構築

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Author: 内田, 博久ほか

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Publication date: 2010-09-27

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Note (General)：: 金沢大学理工研究域フロンティア工学系超臨界溶体急速膨張(RESS)法に必要不可欠な知見である超臨界二酸化炭素に対する4種の医薬用有機物の溶解度,および11種の二酸化炭素+医薬用有機物系の気液固三相平衡関係を測定した.また,RESS法によるRS-(±)-イブプロフェン,アセチルサリチル酸およびテオフィ...

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Material Type: 文書・図像類
Title: 超臨界溶体急速膨張法を利用した医薬用有機ナノ粒子設計技術の実用化基盤の構築
Author/Editor: 内田, 博久
Uchida, Hirohisa
Author Heading: 内田, 博久
Uchida, Hirohisa
Publication Date: 2010-09-27
Publication Date (W3CDTF): 2010-09-27
Alternative Title: Development of basic technologies for the practical production and particulate design of pharmaceutical organic nanopaticles by the rapid expansion of superctritical solutions (RESS) technique
Periodical title: 平成21(2009)年度科学研究費補助金若手研究(B) 研究成果報告書 = 2009 Fiscal Year Final Research Report
No. or year of volume/issue: 2007-2009
Volume: 2007-2009
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 超臨界二酸化炭素
医薬用有機物
超臨界溶体急速膨張法
晶析
ナノ粒子
粒子設計
溶解度
気液固三相平衡
Target Audience: 一般
Note (General): 金沢大学理工研究域フロンティア工学系
超臨界溶体急速膨張(RESS)法に必要不可欠な知見である超臨界二酸化炭素に対する4種の医薬用有機物の溶解度,および11種の二酸化炭素+医薬用有機物系の気液固三相平衡関係を測定した.また,RESS法によるRS-(±)-イブプロフェン,アセチルサリチル酸およびテオフィリンの微粒子創製を検討し,形態が球形,粒径分布が狭く平均粒径が200nm程度であるナノ粒子創製に成功した.さらに,RESS法による粒子特性は,溶体生成部と粒子回収部間の過飽和度により制御可能であるという粒子設計法を提案した.
The solubility of four pharmaceutical organic compounds in supercritical carbon dioxide and the solid-liquid-gas three-phase equilibria for eleven carbon dioxide + pharmaceutical organic compound systems, which are very important to understand and design the rapid expansion of supercritical solutions (RESS) technique, were measured. The nano-sized spherical particles (dav ≈ 200 nm) with the narrow particle size distribution of RS-(±)-ibuprofen, acetylsalicylic acid and theophylline were produced by the RESS technique. The properties of the nanoparticles produced by the RESS technique were found to be controlled by the supersaturation defined as the difference between the chemical potential of the solute at the section of preparing the supercritical solution saturated with the solute and that at the section of the collection of the produced particles.
出典：研究課題「超臨界溶体急速膨張法を利用した医薬用有機ナノ粒子設計技術の実用化基盤の構築」課題番号19686046（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19686046/19686046seika/）を加工して作成
DOI: 10.24517/00052367
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=70313294
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19686046/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19686046/19686046seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA