昆虫変態の分子機構: インスリン様ペプチドの作用と代謝制御

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Author: 岩見, 雅史ほか

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Publication date: 2015-05-11

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Note (General)：: 金沢大学理工研究域生命理工学系カイコガをモデルに，(1) 昆虫変態に関わるインスリン様ホルモン（ボンビキシン）について，ゲノム情報を基に，新規遺伝子の同定を含め全貌を解明した。(2) インスリン機能に関連して，発生に伴うエネルギー源としての糖に着目し体内濃度の変化を解析した。結果，発生過程での糖利用...

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https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22380034/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22380034/22380034seika/

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Material Type: 文書・図像類
Title: 昆虫変態の分子機構: インスリン様ペプチドの作用と代謝制御
Author/Editor: 岩見, 雅史
Iwami, masafumi
Author Heading: 岩見, 雅史
Iwami, masafumi
Publication Date: 2015-05-11
Publication Date (W3CDTF): 2015-05-11
Alternative Title: Molecular Mechanism of Insect Metamorphosis: Action of Insulin-related Peptide
Periodical title: 平成26(2014)年度科学研究費補助金基盤研究(B) 研究成果報告書 = 2014 Fiscal Year Final Research Report
No. or year of volume/issue: 2010-04-01 - 2015-03-31
Volume: 2010-04-01 - 2015-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 昆虫
脱皮・変態
発生・分化
脳・神経
ホルモン
Target Audience: 一般
Note (General): 金沢大学理工研究域生命理工学系
カイコガをモデルに，(1) 昆虫変態に関わるインスリン様ホルモン（ボンビキシン）について，ゲノム情報を基に，新規遺伝子の同定を含め全貌を解明した。(2) インスリン機能に関連して，発生に伴うエネルギー源としての糖に着目し体内濃度の変化を解析した。結果，発生過程での糖利用酵素の活性調節が幼虫期ではエクジソンによる制御機構下にあることを示した。(3) 脳中枢神経回路での情報処理および制御機構解明のため，性フェロモンに対する性行動をモデルに，神経活動依存的遺伝子を用いて神経回路可視化可能系統の作出を試みた。結果，性フェロモンに応答してGFPシグナルが観察され，神経回路の可視化可能系統が確立できた。
Insect brain plays central role during the development by orchestrating hormone production and processing information of internal and external factors. An insulin family peptide, bombyxin, is one of the hormones regulating growth, metabolism, and reproduction, but its function still remains obscure. (1) We analyzed the full silkmoth genome and identified five novel bombyxin families with their genomic organization and chromosomal location. (2) We indicated that the dietary carbohydrates hydrolyzing activity remained high throughout the last larval period and decreased to negligible levels until the pupal period and that the activity is developmentally regulated by ecdysone.To elucidate the brain function at the neural circuit level, we intended to visualize neural circuit underlying sex pheromone-induced innate behavior. (3) We established strains in which we could visualize neural projections and cell nucleus positions that were reliably labeled with GFP after pheromone stimulation.
研究課題/領域番号:22380034, 研究期間(年度):2010-04-01 - 2015-03-31
DOI: 10.24517/00052828
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=40193768
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22380034/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22380034/22380034seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA