PC cine MRIによる血流動態に依存しない頭蓋内脳脊髄液循環動態解析

Material type: 文書・図像類

Author: 宮地, 利明ほか

Publisher: 金沢大学医薬保健研究域保健学系

Publication date: 2003-03

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Note (General)：: 正常圧水頭症(NPH)における頭蓋内の力学的特性を明らかにするために,phase contrast(PC)cine MRIを使用してdriving vascular pulsationと中脳水道における脳脊髄液(CSF)流量波形から算出した周波数位相伝達関数(PTF)を評価した.中脳水道長軸上の中点...

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Material Type: 文書・図像類
Title: PC cine MRIによる血流動態に依存しない頭蓋内脳脊髄液循環動態解析
Author/Editor: 宮地, 利明
Miyati, Toshiaki
Author Heading: 宮地, 利明
Miyati, Toshiaki
Publication, Distribution, etc.: 金沢大学医薬保健研究域保健学系
Publication Date: 2003-03
Publication Date (W3CDTF): 2003-03
Alternative Title: Hemodynamically independent analysis of intracranial cerebrospinal fluid dynamics using PC cine MRI
Periodical title: 平成14(2002)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2002 Fiscal Year Final Research Report
No. or year of volume/issue: 2001-2002
Volume: 2001-2002
Pages: 2p.-
Text Language Code: jpn
Subject Heading: 磁気共鳴画像(MRI)
周波数解析
正常圧水頭症
Cine MRI
Phase contrast
位相伝達関数
コンプライアンス
脳脊髄液循環動態
Magnetic resonance image : MRI
Frequency analysis
Normal pressure hydrocephalus
Phase transfer function
Compliance
Cerebrospinal fluid dynamics
Target Audience: 一般
Note (General): 正常圧水頭症(NPH)における頭蓋内の力学的特性を明らかにするために,phase contrast(PC)cine MRIを使用してdriving vascular pulsationと中脳水道における脳脊髄液(CSF)流量波形から算出した周波数位相伝達関数(PTF)を評価した.中脳水道長軸上の中点の垂直面において,CSF流量波形と血流量波形を心電同期PC cine MRIを使用して測定した.各心時相における脳へ流入する動脈と脳から流出する静脈の差分を入力関数(driving vascular pulsation), CSF流量波形を出力関数として,力学的特性に関与するPTFを両関数から算出した.くも膜下出血後のNPH症例(SAH-NPH)およびSAH-NPHのシャント手術後例,健康正常ボランティアについてPTFを測定した.また,acetazolamide経静脈注入(脳血液量上昇)5分後においてもPTFを測定した.さらに頭蓋内コンプライアンスの指標であるpressure volume response(PVR)とPTFを比較した.SAH-NPH群の基本波におけるPTFは,健康正常ボランティア群よりも有意に大きかった.また,SAH-NPHシャント手術後群のPTFは,健康正常ボランティア群と同一傾向を呈した.acetazolamide注入後のPTFは,注入前と比較して全周波数において有意な差が認められなかった.これはPTFが血流動態に依存しないことを示している.基本波におけるPTFとPVRは正の相関が認められた.PC cine MRIを使用してPTFを解析することで,NPH症例における頭蓋内の力学的特性が非侵襲的に得られる.
To clarify intracranial dynamical properties in normal pressure hydrocephalus (NPH), we assessed a spectral phase transfer function (PTF) calculated from the driving vascular pulsation and cerebrospinal fluid (CSF) flow in the aqueduct using phase contrast (PC) cine MRI.On a vertical plane against a mid-point on the long axis of the aqueduct, both CSF flow and blood flow waveforms were measured with cardiac triggered PC cine MRI. Taking the difference in each cardiac phase between arterial inflow and venous outflow in the brain as the input function (driving vascular pulsation), and the CSF flow in the aqueduct as the output function, the PTF related to the dynamical properties was calculated from both functions. The PTF was determined in patients with NPH after a subarachnoid hemorrhage (SAH-NPH), in an SAH-NPH post-shunt operation group, and in healthy volunteers (control group). The PTF(f)s were also measured 5 min after an intravenous injection of acetazolamide (increase of cerebral blood volume). The PTF was compared with the pressure volume response (PVR) as an index of the intracranial compliance.The PTF of the 1st harmonic in the SAH-NPH group was significantly larger than in the control group, and the PTF in the SAH-NPH post-shunt operation group tends to be closer to that in the control group than the SAH-NPH group. There was no significant difference in PTF before and after acetazolamide injection at any frequency ; independent of hemodynamics. A positive correlation was noted between the PTFPTF analysis with PC cine MRI makes it possible to obtain information noninvasively on intracranial dynamical properties in cases of NPH.
研究課題/領域番号:13670923, 研究期間(年度):2001-2002
出典：「PC cine MRIによる血流動態に依存しない頭蓋内脳脊髄液循環動態解析」研究成果報告書　課題番号13670923 (KAKEN：科学研究費助成事業データベース（国立情報学研究所）)　　　本文データは著者版報告書より作成
DOI: 10.24517/00053199
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=80324086
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670923/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-13670923/136709232002kenkyu_seika_hokoku_gaiyo/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA