マイクロRNAによるOATP輸送体の発現調節機構に基づく薬物療法最適化

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Author: 玉井, 郁巳ほか

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Publication date: 2018-06-28

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Note (General)：: 金沢大学医薬保健研究域薬学系OATPなど薬物動態を左右する輸送体の活性変動機構として新たにマイクロRNA（miRNA)の関与に関する検討を行った。その結果、消化管、肝臓両組織で機能するOATP2B1の発現に関与するmiRNAの同定に至った。さらにOATP基質となるスタチン類に伴う筋毒性診断に応用可能...

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https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15158/

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Material Type: 文書・図像類
Title: マイクロRNAによるOATP輸送体の発現調節機構に基づく薬物療法最適化
Author/Editor: 玉井, 郁巳
Tamai, Ikumi
Author Heading: 玉井, 郁巳
Tamai, Ikumi
Publication Date: 2018-06-28
Publication Date (W3CDTF): 2018-06-28
Alternative Title: Micro RNA-mediated expressional regulation of transporters
Periodical title: 平成29(2017)年度科学研究費補助金挑戦的萌芽研究研究成果報告書 = 2017 Fiscal Year Final Research Report
No. or year of volume/issue: 2016-04-01 - 2018-03-31
Volume: 2016-04-01 - 2018-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: トランスポーター
OATP
マイクロRNA
ナノ粒子
薬食相互作用
薬物間相互作用
個体間変動
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域薬学系
OATPなど薬物動態を左右する輸送体の活性変動機構として新たにマイクロRNA（miRNA)の関与に関する検討を行った。その結果、消化管、肝臓両組織で機能するOATP2B1の発現に関与するmiRNAの同定に至った。さらにOATP基質となるスタチン類に伴う筋毒性診断に応用可能な新規miRNAを示唆するに至ることができた。一方、食品との薬物の相互作用機構としてのmiRNAの検討も並行して進めた結果、リンゴ由来ナノ粒子に含まれるmiRNAが消化管輸送体の発現調節に働く可能性を示唆することもできた。一方、新たに消化管で薬物吸収に寄与する核酸輸送体の同定にも成功した。
To understand the mechanisms for altered drug absorption and disposition by co-administered drugs and foods, we studied possible involvement of micro RNA (miRNA) on the expressional regulation of drug transporter OATPs. (1) OTAP2B1, which is expressed both in liver and intestine, was found to be regulated by specific miRNA by in vitro experiments. (2) Statins are very good substrates of OATPs and they have possibility to cause myopathy as side effect. We succeeded to suggest several miRNA that can be used for diagnosis of myopathy. (3) As the mechanism of drug-food interaction, it was demonstrated that apple-derived nanoparticles include many miRNAs and they affect expression of OATP2B1, suggesting that food-derived miRNAs could regulate expression of OATPs, (4) Transporters responsible for intestinal absorption of anti-cancer nucleoside analogue were identified and further studies to demonstrate the mechanisms to regulate their expression, including miRNA should be conducted.
研究課題/領域番号:16K15158, 研究期間(年度):2016-04-01 - 2018-03-31
出典：研究課題「マイクロRNAによるOATP輸送体の発現調節機構に基づく薬物療法最適化」課題番号16K15158（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K15158/16K15158seika/）を加工して作成
DOI: 10.24517/00050915
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=20155237
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15158/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K15158/16K15158seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA