多孔質足場を用いた動脈瘤開口部の新生血管壁構造の誘導実験

Material type: 文書・図像類

Author: 内山, 尚之ほか

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Publication date: 2018-05-18

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Note (General)：: 金沢大学附属病院脳神経外科ラット脳動脈瘤内に多孔質足場（セルロースポーラスビーズ，cellulose porous bead: CPB）を留置することにより，動脈瘤開口部に新生内膜構造が誘導され，動脈瘤内への血流が永続的に遮断されるか否かを確認した．動脈瘤開口部にはCPB留置後2週間目で，血管平滑筋...

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Material Type: 文書・図像類
Title: 多孔質足場を用いた動脈瘤開口部の新生血管壁構造の誘導実験
Author/Editor: 内山, 尚之
Uchiyama, Naoyuki
Author Heading: 内山, 尚之
Uchiyama, Naoyuki
Publication Date: 2018-05-18
Publication Date (W3CDTF): 2018-05-18
Alternative Title: Regeneration of vessel walls using a porous scaffold in an external carotid artery aneurysm model in rats
Periodical title: 平成29(2017)年度科学研究費補助金基盤研究(B) 研究成果報告書 = 2017 Fiscal Year Final Research Report
No. or year of volume/issue: 2015-04-01 - 2018-03-31
Volume: 2015-04-01 - 2018-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: aneurysm
embolization
neck orifice
porous scaffold
Target Audience: 一般
Note (General): 金沢大学附属病院脳神経外科
ラット脳動脈瘤内に多孔質足場（セルロースポーラスビーズ，cellulose porous bead: CPB）を留置することにより，動脈瘤開口部に新生内膜構造が誘導され，動脈瘤内への血流が永続的に遮断されるか否かを確認した．動脈瘤開口部にはCPB留置後2週間目で，血管平滑筋細胞が一層形成された．この層は6週目まで徐々に肥厚し，以後その厚さを維持した．また血管平滑筋細胞の内側には血管内皮細胞が2週目より出現し，6週目までに開口部を完全に覆っていた．CPBは動脈瘤開口部に新生内膜を誘導する有用な足場となる可能性がある．
Regeneration of the vessel wall structure at the aneurysmal neck orifice is important but does not readily occur with coil embolization, which is commonly used to treat cerebral aneurysms. To promote vessel wall regeneration, a scaffold of cellulose porous bead (CPB) was used as a material for aneurysm embolization. A rat external carotid artery (ECA) aneurysm model was created, and a single CPB with a diameter similar to the diameter of the ECA was placed in the aneurysm. The layer of regenerating αSMA-positive spindle cells at the aneurysm neck orifice was recognized as early as 2 weeks after implantation of the CPB, and maintained its thickness by 6 months. A monolayer of factor VIII-positive cells appeared at the neck at 2 weeks, and covered the entire neck by 6 months. CPBs might be appropriate as an embolization material for inducing vessel wall regeneration at the neck of an aneurysm.
研究課題/領域番号:15K10295, 研究期間(年度):2015-04-01 - 2018-03-31
出典：研究課題「多孔質足場を用いた動脈瘤開口部の新生血管壁構造の誘導実験」課題番号15K10295（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10295/15K10295seika/）を加工して作成
DOI: 10.24517/00051274
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=80293364
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10295/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-15K10295/15K10295seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA