モデルマウスを用いたIgG4関連疾患の病態の解明と治療法の確立

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Author: 川野, 充弘ほか

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Publication date: 2017-05-25

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Note (General)：: 金沢大学附属病院リウマチ・膠原病内科本研究ではIgG4関連疾患（IgG4-RD）におけるAPRILの意義について検討した。IgG4関連腎臓病患者の腎組織において、APRILの発現亢進及び治療後の発現低下が認められた。主なAPRIL産生細胞はM2マクロファージであった。IgG4-RDのモデル動物である...

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https://kaken.nii.ac.jp/search/?qm=20361983

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461487/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461487/26461487seika/

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Material Type: 文書・図像類
Title: モデルマウスを用いたIgG4関連疾患の病態の解明と治療法の確立
Author/Editor: 川野, 充弘
Kawano, Mitsuhiro
Author Heading: 川野, 充弘
Kawano, Mitsuhiro
Publication Date: 2017-05-25
Publication Date (W3CDTF): 2017-05-25
Alternative Title: Elucidation of a pathogenesis of IgG4-related disease and establishment of a novel treatment
Periodical title: 平成28(2016)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 - 2017-03-31
Volume: 2014-04-01 - 2017-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: IgG4関連疾患
APRIL
BAFF
Target Audience: 一般
Note (General): 金沢大学附属病院リウマチ・膠原病内科
本研究ではIgG4関連疾患（IgG4-RD）におけるAPRILの意義について検討した。IgG4関連腎臓病患者の腎組織において、APRILの発現亢進及び治療後の発現低下が認められた。主なAPRIL産生細胞はM2マクロファージであった。IgG4-RDのモデル動物であるLat Y136F knock-in miceにおいても病変部位にAPRILの発現を認め、APRIL阻止抗体の投与により腎病変の進展が抑制された。さらに、ヒトおよびLat Y136F knock-in miceの病変部位にBAFFの高発現も認めた。以上より、IgG4-RDの病態形成にAPRILおよびBAFFが関与していると考えられた。
The purpose of this study was to analyze the role of a proliferation-inducing ligand (APRIL) in patients with IgG4-related disease (IgG4-RD). APRIL was expressed in kidney inflammation, and corticosteroid treatment decreased the expression of APRIL in the renal tissue of patients with IgG4-related kidney disease. We found that the main APRIL-producing cells were M2 macrophages. We also confirmed the expression of APRIL in the inflammatory lesion of Lat Y136F knock-in mice. Treatment with APRIL-blocking antibody suppressed the development of the kidney lesions in these mice. Furthermore, we confirmed the high expression level of BAFF in the lesions of patients with IgG4-RD and Lat Y136F knock-in mice. These data indicate that APRIL and BAFF are related to the pathogenesis of IgG4-RD.
研究課題/領域番号:26461487, 研究期間(年度):2014-04-01 - 2018-03-31
DOI: 10.24517/00056722
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=20361983
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461487/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-26461487/26461487seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA