癌幹細胞を標的とした婦人科癌治療ならびに腫瘍細胞イメージングシステムの構築

Material type: 文書・図像類

Author: 高倉, 正博ほか

Publisher: 金沢大学附属病院

Publication date: 2014-05-27

Material Format: Digital

Capacity, size, etc.: -

NDC: -

View All

Notes on use

Note (General)：: 本研究ではテロメラーゼが活性化された細胞でのみ増殖可能な改変型アデノウイルス（Telomerase-specific replication adenovirus:TRAD）が抗癌剤耐性の婦人科癌がん幹細胞候補に対して有効に作用することを示した。またGFP発現型TRADを用いて末梢血中の腫瘍細胞（c...

Related materials as well as pre- and post-revision versions

https://kaken.nii.ac.jp/search/?qm=20313661

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592439/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592439/23592439seika/

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Kanazawa University Repository for Academic Resources
Digital
You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
Kanazawa University Repository for Academic Resources

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 文書・図像類
Title: 癌幹細胞を標的とした婦人科癌治療ならびに腫瘍細胞イメージングシステムの構築
Author/Editor: 高倉, 正博
Takakura, Masahiro
Author Heading: 高倉, 正博
Takakura, Masahiro
Publication, Distribution, etc.: 金沢大学附属病院
Publication Date: 2014-05-27
Publication Date (W3CDTF): 2014-05-27
Alternative Title: Establishment of cancer virotherapy and imaging system targeting cancer stem cells in gynecologic cancer
Periodical title: 平成25(2013)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2013 Fiscal Year Final Research Report
No. or year of volume/issue: 2011-2013
Volume: 2011-2013
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 癌幹細胞
末梢血中腫瘍細胞
テロメラーゼ
Target Audience: 一般
Note (General): 本研究ではテロメラーゼが活性化された細胞でのみ増殖可能な改変型アデノウイルス（Telomerase-specific replication adenovirus:TRAD）が抗癌剤耐性の婦人科癌がん幹細胞候補に対して有効に作用することを示した。またGFP発現型TRADを用いて末梢血中の腫瘍細胞（circulating tumor cells: CTC）を検出した。初発・再発を含む婦人科癌症例での検討において約40％の症例でCTCが認められた。CTCは臨床進行期や病理組織型といった既存の臨床病理学的因子との間には相関は認められなかったが、治療開始後もCTCが存在し続ける症例は予後不良であった。
We have established telomerase-specific replication-selective adenoviruses (TRAD) which can replicate only in telomerase activated cells. In the present study, we assessed the effectiveness of TRAD to the candidates of cancer stem cells in gynecologic cancer.We have also developed a detection system for circulating tumor cells (CTCs) using GFP expressing TRAD. CTCs were detected in 40% of patients with gynecological malignancies. There was no significant correlation between CTC counts and tumor types or known clinicopathological factors, such as clinical stage and histological type. The CTCs rapidly vanished after surgery or chemotherapy in most patients whose treatments were effective. In contrast, the persistence of CTCs even after treatments was tightly associated with poor response to the treatments (P<0.005).
研究課題/領域番号:23592439, 研究期間(年度):2011-2013
出典：「癌幹細胞を標的とした婦人科癌治療ならびに腫瘍細胞イメージングシステムの構築」研究成果報告書　課題番号23592439（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592439/23592439seika/)を加工して作成
DOI: 10.24517/00056931
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=20313661
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592439/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23592439/23592439seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA