精神神経疾患の個体差を克服する個別化薬物療法に有用な分子標的放射性診断薬の開発

Material type: 文書・図像類

Author: 川井, 惠一ほか

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Publication date: 2017-05-19

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Note (General)：: 金沢大学医薬保健研究域保健学系本研究では、精神神経疾患薬物療法の最適化を目的として、疾患モデル動物に種々の治療薬を投与し、神経機能に関連する放射性プローブを用いたイメージングにより同一個体における機能変化を評価するとともに、脳内遺伝子発現レベルの変化を解析し、薬効の個体差要因を検討した。さらに、治療...

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https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293260/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25293260/25293260seika/

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Material Type: 文書・図像類
Title: 精神神経疾患の個体差を克服する個別化薬物療法に有用な分子標的放射性診断薬の開発
Author/Editor: 川井, 惠一
Kawai, Keiichi
Author Heading: 川井, 惠一
Kawai, Keiichi
Publication Date: 2017-05-19
Publication Date (W3CDTF): 2017-05-19
Alternative Title: Development of a molecular targeted radiolabeled diagnostic agent usuful for personalized drug therapy of psychoneurotic diseases
Periodical title: 平成28(2016)年度科学研究費補助金基盤研究(B) 研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2013-04-01 - 2017-03-31
Volume: 2013-04-01 - 2017-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 精神神経疾患
遺伝子発現解析
治療効果
個体差要因
薬物代謝酵素活性
分子イメージング
個別化薬物療法
放射性画像診断薬
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域保健学系
本研究では、精神神経疾患薬物療法の最適化を目的として、疾患モデル動物に種々の治療薬を投与し、神経機能に関連する放射性プローブを用いたイメージングにより同一個体における機能変化を評価するとともに、脳内遺伝子発現レベルの変化を解析し、薬効の個体差要因を検討した。さらに、治療効果に大きく影響する薬物代謝酵素活性や薬物動態の個体差要因となる機能性分子活性変動を患者個々に解析し、個別化薬物療法の基盤を与える新規分子標的放射性画像診断薬の開発を試みた。
In this study, in order to optimize drug therapy for psychoneurotic diseases, various therapeutic agents were administered to diseased model animals, functional changes in the same individual were evaluated by imaging using a radioactive probe related to nerve function, Changes in gene expression levels in the brain were analyzed, and factors of individual differences in efficacy were examined. In addition, the individual changes of functional molecular activity as an individual difference factor of drug metabolizing enzyme activity and pharmacokinetics were analyzed, and development of a novel biomolecule-targeted radiopharmaceutical that gives the basis of individualized drug therapy were attempted.
研究課題/領域番号:25293260, 研究期間(年度):2013-04-01 - 2017-03-31
DOI: 10.24517/00057096
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=30204663
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293260/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-25293260/25293260seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA