ゲノムの低メチル化とレトロポゾンの活性化を特徴とする大腸がんの診断・治療開発

Material type: 文書・図像類

Author: 川上, 和之ほか

Publisher: 金沢大学がん研究所

Publication date: 2014-05-20

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Note (General)：: We investigated the mechanism by which 5-FU is effective on the tumor with LINE-1 hypomethylation. LINE-1 expression status is not associated with tum...

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Material Type: 文書・図像類
Title: ゲノムの低メチル化とレトロポゾンの活性化を特徴とする大腸がんの診断・治療開発
Author/Editor: 川上, 和之
Kawakami, Kazuyuki
Author Heading: 川上, 和之
Kawakami, Kazuyuki
Publication, Distribution, etc.: 金沢大学がん研究所
Publication Date: 2014-05-20
Publication Date (W3CDTF): 2014-05-20
Alternative Title: Molecular analysis of colorectal cancer with LINE-1 hypomethylation and its application to cancer diagnosis and therapy
Periodical title: 平成25(2013)年度科学研究費補助金基盤研究(B) 研究成果報告書 = 2013 Fiscal Year Final Research Report
No. or year of volume/issue: 2011-04-01 - 2014-03-31
Volume: 2011-04-01 - 2014-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 大腸がん
レトロポゾン
メチル化
抗がん剤
Target Audience: 一般
Note (General): We investigated the mechanism by which 5-FU is effective on the tumor with LINE-1 hypomethylation. LINE-1 expression status is not associated with tumor sensitivity to 5-FU. Chromatin structure looses in the tumor with LINE-1 hypomethylation. Colorectal cancer cell with loosed chromatin is more sensitive to 5-FU compared to one with condensed chromatin. The results suggest that the association between LINE-1 hypomethylation and chromatin structure underlies mechanism of anticancer activity of 5-FU. Knockdown of LINE-1 expression results in suppression of cancer growth. Many anticancer drugs inhibit LINE-1 expression, suggesting that suppression of LINE-1 might be one of mechanism by which 5-FU and other anticancer drugs shows synergistic effect. These findings could be important for achieving personalized chemotherapy and developing novel strategy using 5-FU.
ヒトの主要なレトロポゾンであるLINE-1が低メチル化により活性化している大腸がんにおいて、5-FUの効果が高いメカニズムを解析した。その結果、LINE-1の発現自体は直接5-FUの効果に影響を与えておらず、LINE-1の低メチル化によりクロマチン構造が弛緩することが5-FUの効果に関与していると判明した。LINE-1の発現亢進は細胞障害よりもむしろ細胞増殖に関与しており、5-FUとの併用効果を認める抗がん剤ではLINE-1の発現を抑制することが抗腫瘍効果発現メカニズムの1つであると示唆された。
研究課題/領域番号:23390321, 研究期間(年度):2011-04-01 - 2014-03-31
出典：「ゲノムの低メチル化とレトロポゾンの活性化を特徴とする大腸がんの診断・治療開発」研究成果報告書　課題番号23390321（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390321/23390321seika/)を加工して作成
DOI: 10.24517/00057338
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=00293358
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390321/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-23390321/23390321seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA