大腸がんにおけるDNAメチル化の調節機構解明と遺伝子診断・治療への応用

Material type: 文書・図像類

Author: 川上, 和之ほか

Publisher: 金沢大学がん研究所

Publication date: 2011-05-23

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Note (General)：: We investigated the clinical value of methylation profile for the prognosis of colorectal cancer (CRC) and for the survival benefit from adjuvant chem...

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Material Type: 文書・図像類
Title: 大腸がんにおけるDNAメチル化の調節機構解明と遺伝子診断・治療への応用
Author/Editor: 川上, 和之
Kawakami, Kazuyuki
Author Heading: 川上, 和之
Kawakami, Kazuyuki
Publication, Distribution, etc.: 金沢大学がん研究所
Publication Date: 2011-05-23
Publication Date (W3CDTF): 2011-05-23
Alternative Title: Mechanistic analysis on DNA methylation in colorectal cancer and its application to diagnosis and therapy
Periodical title: 平成22(2010)年度科学研究費補助金基盤研究(B) 研究成果報告書 = 2010 Fiscal Year Final Research Report
No. or year of volume/issue: 2008-2010
Volume: 2008-2010
Pages: 5p.-
Text Language Code: jpn
Subject Heading: 大腸がん
メチル化
抗がん剤
Target Audience: 一般
Note (General): We investigated the clinical value of methylation profile for the prognosis of colorectal cancer (CRC) and for the survival benefit from adjuvant chemotherapy with oral fluoropyrimidines. CpG island methylator phenotype (CIMP) was relatively rare in Japan and its clinical value is limited. In contrast, methylation of long interspersed nuclear element-1 (LINE-1) was a potential predictive marker for survival benefit from adjuvant chemotherapy with oral fluoropyrimidines in CRC patients. CRC cell lines treated with 5-FU showed increased expression of LINE-1 mRNA. This was associated with upregulation of the phospho-histone H2A. X in cells with low LINE-1 methylation, but not in cells with high LINE-1 methylation. The 5-FU-mediated induction of phospho-histone H2A. X, a marker of DNA damage, was inhibited by knockdown of LINE-1. These findings could be important for achieving personalized chemotherapy.
大腸がんのメチル化プロファイルを解析し、メチル化マーカーの臨床応用法を検討した。その結果、long interspersed nuclear element 1(LINE-1)メチル化の測定は予後予測と術後フッ化ピリミジン系経口抗癌剤による補助治療効果の予測の両方に有用であると考えられた。大腸がん細胞で検討すると、LINE-1の発現は5-FUにより増加し、同時にDNAの損傷が誘導されることからLTNE-1がコードするDNA切断酵素活性が5-FUの効果発現に関与していると示唆された。
研究課題/領域番号:20390353, 研究期間(年度):2008-2010
出典：研究課題「大腸がんにおけるDNAメチル化の調節機構解明と遺伝子診断・治療への応用」課題番号20390353（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390353/20390353seika/）を加工して作成
DOI: 10.24517/00057339
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=00293358
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390353/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-20390353/20390353seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA