癌細胞浸潤を阻害抑制する因子の解明

Material type: 文書・図像類

Author: 中村, 律子ほか

Publisher: 金沢大学医薬保健研究域医学系

Publication date: 2019-05-16

Material Format: Digital

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Note (General)：: 本研究ではNeural EFGL like (NELL)の乳癌における発現および機能解析を行った。乳腺組織ではNELL2は筋上皮細胞, NELL2のレセプターであるRoundabout Guidance Receptor 3 (ROBO3)は乳管上皮および乳癌細胞で発現していた。NELL2とレセプタ...

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https://kaken.nii.ac.jp/search/?qm=20632657

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07165/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K07165/16K07165seika/

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Material Type: 文書・図像類
Title: 癌細胞浸潤を阻害抑制する因子の解明
Author/Editor: 中村, 律子
Nakamura, Ritsuko
Author Heading: 中村, 律子
Nakamura, Ritsuko
Publication, Distribution, etc.: 金沢大学医薬保健研究域医学系
Publication Date: 2019-05-16
Publication Date (W3CDTF): 2019-05-16
Alternative Title: Study of the suppressor protein of cancer cell invasion
Periodical title: 平成30(2018)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2018 Fiscal Year Final Research Report
No. or year of volume/issue: 2016-04-01 - 2019-03-31
Volume: 2016-04-01 - 2019-03-31
Pages: 5p.-
Text Language Code: jpn
Subject Heading: 浸潤
細胞移動
乳癌
NELL
Target Audience: 一般
Note (General): 本研究ではNeural EFGL like (NELL)の乳癌における発現および機能解析を行った。乳腺組織ではNELL2は筋上皮細胞, NELL2のレセプターであるRoundabout Guidance Receptor 3 (ROBO3)は乳管上皮および乳癌細胞で発現していた。NELL2とレセプターの反発作用による細胞の住み分けを想定し、in vitroでの細胞移動阻害を確認したところ全長NELL2およびC末欠損型NELL2が乳癌細胞の移動を抑制した。乳癌細胞表面へのNELLの結合は、TSPドメインが関与していた。
In this study, we demonstrated the expression and function of Neural EGFL like (NELL), which is a secretory protein in breast tissues. NELL2 was expressed in the myoepithelial cells, and Roundabout Guidance Receptor 3 (ROBO3), which is one of the receptors of NELL2, was expressed in the luminal epithelial cells and breast cancer cells. From the breast ductal structure that composed inside of the luminal epithelial cells and outside of the myoepithelial cells, we suspected the distribution of these cells by ligand (NELL2)-receptor (ROBO3) repulsion. N-terminal thrombospondin-like (TSP) domain contained constructs were bound the surface of breast cancer cell lines. Full-length NELL2 and c-terminal deleted NELL2 construct suppressed the breast cancer cell migration in vitro, however, TSP domain alone was increased migrated cells. It might be suggested that TSP domain of NELL2 related to the binding on the surface of breast cancer cells, but not enough for the cell repulsive signal.
研究課題/領域番号:16K07165, 研究期間(年度):2016-04-01 - 2019-03-31
出典：研究課題「癌細胞浸潤を阻害抑制する因子の解明」課題番号16K07165（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K07165/16K07165seika/)を加工して作成
DOI: 10.24517/00054532
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=48210&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=48210&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/search/?qm=20632657
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07165/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K07165/16K07165seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA