悪性胸膜中皮腫に対する新規強磁性体温熱療法とmTOR阻害剤の併用療法の開発

Material type: 文書・図像類

Author: 田村, 昌也ほか

Publisher: 金沢大学附属病院呼吸器外科

Publication date: 2019-09-05

Material Format: Digital

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Note (General)：: 共同研究施設より貸与をうけた磁性流体を用い、細胞への磁性流体への取り込みを確認する実験を追加して行った。細胞株211Hに磁性流体を添付した溶液を遠心分離し、その上清、細胞の各々のFe含有量をICP-MS法にて測定した。細胞成分にFeの取り込みが確認できた。小型動物を加温する加温器を本学工学部と作成し...

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https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10702/

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Material Type: 文書・図像類
Title: 悪性胸膜中皮腫に対する新規強磁性体温熱療法とmTOR阻害剤の併用療法の開発
Author/Editor: 田村, 昌也
Tamura, Masaya
Author Heading: 田村, 昌也
Tamura, Masaya
Publication, Distribution, etc.: 金沢大学附属病院呼吸器外科
Publication Date: 2019-09-05
Publication Date (W3CDTF): 2019-09-05
Alternative Title: Combined treatment of hyperthermia therapy using novel ferromagnet and mTOR inhibitor for malignant pleural mesothelioma
Periodical title: 平成30(2018)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2018 Fiscal Year Final Research Report
No. or year of volume/issue: 2016-04-01 - 2019-03-31
Volume: 2016-04-01 - 2019-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 悪性胸膜中皮腫
温熱療法
化学療法
Target Audience: 一般
Note (General): 共同研究施設より貸与をうけた磁性流体を用い、細胞への磁性流体への取り込みを確認する実験を追加して行った。細胞株211Hに磁性流体を添付した溶液を遠心分離し、その上清、細胞の各々のFe含有量をICP-MS法にて測定した。細胞成分にFeの取り込みが確認できた。小型動物を加温する加温器を本学工学部と作成し、小型動物（ヌードマウス：250g）の加温実験を行った。腹部皮下に1mlの磁性流体を注入し、加温を行った。2~5分で42-42℃の温度上昇を得た。5匹に実験を施行し、全例加温後も生存を確認した。明らかな有害事象はなかった。
Using the magnetic fluid loaned from the collaborative research facility, experiments were performed to confirm uptake into the magnetic fluid into cells. The magnetic fluid was attached to the cell line 211H, the solution after 24 hours was centrifuged, and the Fe content of each of the supernatant and the cells was measured by ICP-MS methods. The uptake of Fe was confirmed in the cellular components. A small-sized heater for small animals, such as mouse, rat was created. Using this, a heating experiment of a small animals (nude mouse: 250g) was performed. The 1ml magnetic fluid was injected into abdomen subcutaneously. A temperature rise of 42-43℃ was obtained in 2 to 5 minutes. The experiment was conducted on 5 animals and survival was confirmed after heating in all cases. No obvious adverse events such as skin burns were identified.
研究課題/領域番号:16K10702, 研究期間(年度):2016-04-01 - 2019-03-31
出典：研究課題「悪性胸膜中皮腫に対する新規強磁性体温熱療法とmTOR阻害剤の併用療法の開発」課題番号16K10702（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10702/16K10702seika/）を加工して作成
DOI: 10.24517/00054875
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=10397185
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10702/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K10702/16K10702seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA