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血球貪食症候を自然発症する新規動物モデルの開発と発症機構の解析

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血球貪食症候を自然発症する新規動物モデルの開発と発症機構の解析

Material type
文書・図像類
Author
橋本, 憲佳ほか
Publisher
-
Publication date
2009-05-26
Material Format
Digital
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アスパラギンエンドペプチダーゼ(AEP)遺伝子欠損マウスを解析し, 体温上昇, 貧血, 肝脾腫, 骨髄や脾臓における血球貪食細胞の出現など, ヒト血球貪食症候群(HPS)の病態をよく再現したモデルマウスとして位置づけた。血球貪食細胞はマクロファージであり赤血球貪食能は上昇し, 一部でリソソーム病であ...

Related materials as well as pre- and post-revision versions

https://kaken.nii.ac.jp/ja/search/?kw=50242524

https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18500325/

https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18500325/18500325seika/

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Digital

Material Type
文書・図像類
Title
血球貪食症候を自然発症する新規動物モデルの開発と発症機構の解析
Author/Editor
橋本, 憲佳
Hashimoto, Noriyoshi
Author Heading
橋本, 憲佳
Hashimoto, Noriyoshi
Publication Date
2009-05-26
Publication Date (W3CDTF)
2009-05-26
Alternative Title
Characterization of AEP/Legumain-deficient mice as a model of hemophagocytic syndrome-like disease
Periodical title
平成20(2008)年度 科学研究費補助金 基盤研究(C) 研究成果報告書 = 2008 Fiscal Year Final Research Report
No. or year of volume/issue
2006 – 2008
Volume
2006 – 2008