TrkBのリン酸化: 側坐核における薬物依存習慣化の分子スイッチの機序解明と治療法

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Author: 戸田, 重誠ほか

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Publication date: 2013-05-20

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Note (General)：: 金沢大学附属病院神経活動依存性のタンパク質翻訳に関わる分子、TrkBおよびribosomal protein S6(rpS6)のリン酸化は、神経可塑性や学習記憶に関与する。我々はラット側坐核において、TrkBの記憶の統合と獲得にそれぞれ特異的に関与するリン酸化部位、ならびにrpS6でmTOR依存性お...

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Material Type: 文書・図像類
Title: TrkBのリン酸化: 側坐核における薬物依存習慣化の分子スイッチの機序解明と治療法
Author/Editor: 戸田, 重誠
Toda, Shigenobu
Author Heading: 戸田, 重誠
Toda, Shigenobu
Publication Date: 2013-05-20
Publication Date (W3CDTF): 2013-05-20
Alternative Title: The functional significance of TrkB phosphorylation in the rat nucleus accumbens as a molecular switch of habit formation in drug addiction
Periodical title: 平成24(2012)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2012 Fiscal Year Final Research Report
No. or year of volume/issue: 2017-04-01 - 2019-03-31
Volume: 2017-04-01 - 2019-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 精神薬理学
薬物依存
Target Audience: 一般
Note (General): 金沢大学附属病院
神経活動依存性のタンパク質翻訳に関わる分子、TrkBおよびribosomal protein S6(rpS6)のリン酸化は、神経可塑性や学習記憶に関与する。我々はラット側坐核において、TrkBの記憶の統合と獲得にそれぞれ特異的に関与するリン酸化部位、ならびにrpS6でmTOR依存性および非依存性に活性化される2つのリン酸化部位に注目し、対照群と慢性コカイン投与群で、急性コカイン後にそれぞれ異なった活性化が起きることを確認した。動物のコカイン依存行動を正常化するN-アセチルシスティンは、TrkB-mTOR系のリン酸化に影響しなかった。
The phosphorylations of TrkB and ribosomal protein S6 that play crucial roles in activity-dependent protein synthesis contribute to neuronal plasticity and learning/memory. In this study, we examined the effect of cocaine challenge on the important phosphorylation sites of TrkB and rpS6 in the rat nucleus accumbens after repeated saline or cocaine administration. As for TrkB, two distinct phosphorylation sites, one is required for memory acquisition, the other is for memory consolidation, were investigated. Likewise, as for rpS6, two distinct phosphorylation sites, one is mTOR-dependent, other is mTOR-independent, were examined. As a result, we found that the pattern of phosphorylation at each site was so distinctively different between control and chronic-cocaine-treated rats. N-acetylcysteine, which is supposed to restore cocaine-seeking behaviors in rodents did not provide any effect on the phosphorylations in TrkB-mTOT pathway.
研究課題/領域番号:22591257, 研究期間(年度):2010 – 2012
DOI: 10.24517/00059545
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=00323006
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-22591257/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-22591257/22591257seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA