胃癌腹膜播種の微小環境における上皮間葉転換の解明と治療標的の意義

Material type: 文書・図像類

Author: 木下, 淳ほか

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Publication date: 2014-05-21

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Note (General)：: 金沢大学医薬保健研究域医学系胃癌腹膜転移側の宿主細胞である腹膜中皮細胞(HPMC)において、TGF-β1や胃癌細胞との共培養によるEMT(上皮間葉転換）誘導を証明した。またマウス皮下腫瘍モデルを用い、胃癌細胞とHPMCの共投与は腫瘍増殖能や間質線維化の増生に促進的に作用する事を示した。さらにBRM製...

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Material Type: 文書・図像類
Title: 胃癌腹膜播種の微小環境における上皮間葉転換の解明と治療標的の意義
Author/Editor: 木下, 淳
Kinoshita, Jun
Author Heading: 木下, 淳
Kinoshita, Jun
Publication Date: 2014-05-21
Publication Date (W3CDTF): 2014-05-21
Alternative Title: Elucidation of the mechanism of Epithelial-Mesenchymal Transition in peritoneal environment of gastric cancer
Periodical title: 平成26(2014)年度科学研究費補助金若手研究(B) 研究成果報告書 = 2014 Fiscal Year Final Research Report
No. or year of volume/issue: 2012-04-01 – 2014-03-31
Volume: 2012-04-01 – 2014-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 胃癌
腹膜播種
上皮間葉転換
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
胃癌腹膜転移側の宿主細胞である腹膜中皮細胞(HPMC)において、TGF-β1や胃癌細胞との共培養によるEMT(上皮間葉転換）誘導を証明した。またマウス皮下腫瘍モデルを用い、胃癌細胞とHPMCの共投与は腫瘍増殖能や間質線維化の増生に促進的に作用する事を示した。さらにBRM製剤であるPSKは非免疫学的機序である抗TGFβ作用によって、これらのEMT誘導に伴う癌間質の線維化を抑制する事を証明した。
In this study, we evaluated the mechanism of EMT of Human PeritonealMesothelial Cell(HPMC) in in peritoneal environment of gastric cancer. We also investigated the inhibitory effect of PSK on the TGF/Smad signalling pathway and TGFb induced EMT in human HPMCs and gastric cancer cells. In vitro, TGFb increased the expression of E cadherin and decreased the expression of mesenchymal markers in HPMCs and which was suppressed by PSK. PSK suppressed TGFb induced phosphorylation of Smad2 in HPMCs in western blot analysis.In mouse subctaneous xenograft models, PSK inhibited the tumor fibrosis induced by co-inoculation of gastric cancer cells and HPMCs. PSK might have the potential to reduce TGFb induced activation of HPMCs in the peritoneal microenvironment of gastric cancer.
研究課題/領域番号:24791402, 研究期間(年度):2012-04-01 – 2014-03-31
DOI: 10.24517/00058981
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=52687&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=52687&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=90584855
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791402/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791402/24791402seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA