脳血管保護因子: 内在性分泌型RAGEの機能解明と治療への応用

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Author: 清水, 有ほか

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Publication date: 2016-05-24

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Note (General)：: 金沢大学附属病院パターン認識受容体として知られる細胞表面一回膜貫通型受容体Receptor for Advanced Glycation End-products (RAGE）は、虚血性脳血管障害の神経細胞死に関わる。しかしRAGEには分泌型可溶性のスプライシングバリアントが存在し、我々は内在性分泌...

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Material Type: 文書・図像類
Title: 脳血管保護因子: 内在性分泌型RAGEの機能解明と治療への応用
Author/Editor: 清水, 有
Shimizu, Yu
Author Heading: 清水, 有
Shimizu, Yu
Publication Date: 2016-05-24
Publication Date (W3CDTF): 2016-05-24
Alternative Title: Endogenous secretory RAGE as a potential protective factor against ischemic cerebrovascular diseases
Periodical title: 平成27(2015)年度科学研究費補助金若手研究(B) 研究成果報告書 = 2015 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 – 2016-03-31
Volume: 2014-04-01 – 2016-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: esRAGE
神経細胞死
パラバイオーシス
血液脳関門
Target Audience: 一般
Note (General): 金沢大学附属病院
パターン認識受容体として知られる細胞表面一回膜貫通型受容体Receptor for Advanced Glycation End-products (RAGE）は、虚血性脳血管障害の神経細胞死に関わる。しかしRAGEには分泌型可溶性のスプライシングバリアントが存在し、我々は内在性分泌型RAGE（endogenous secretory RAGE, esRAGE）と命名した。esRAGEは、膜型RAGEのデコイとして働き、脳虚血による神経細胞死を抑制した。また、esRAGEが血管内皮細胞の細胞表層のヘパラン硫酸プロテオグリカンと相互作用し、脳血管障害に対する保護因子として作用することを証明した。
Receptor for Advanced Glycation End-products (RAGE) is a pattern-recognition receptor and plays a role in the development of neuronal cell death during and after brain ischemia. RAGE has a splicing variant form, which is soluble and named as endogenous secretory RAGE (esRAGE). esRAGE is considered to work as a decoy-type receptor and attenuate ischemia-induced neuronal cell damages. In this study, we proved that esRAGE can be associated with heparan sulphate proteoglycans (HSPG) on brain endothelial cells and act as a potential protective factor against the ischemic cerebrovascular diseases.
研究課題/領域番号:26861143, 研究期間(年度):2014-04-01 – 2016-03-31
DOI: 10.24517/00059139
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=90646689
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26861143/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26861143/26861143seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA