新規微小管作用薬による胃癌腹膜播種線維化抑制についての実験的検討

Material type: 文書・図像類

Author: 柄田, 智也ほか

Publisher: -

Publication date: 2017-05-30

Material Format: Digital

Capacity, size, etc.: -

NDC: -

View All

Notes on use

Note (General)：: 金沢大学医薬保健研究域医学系胃癌腹膜播種は高度の浸潤能と線維化を伴い化学療法抵抗性を示す。今回、新規微小管重合阻害剤であるエリブリンが胃がんの進展やEMT様変化を抑制するか検討すると同時に、5FUとの併用効果についても検討した。vitroでは、エリブリンは低濃度で胃癌細胞株MKN45の増殖とEMT様...

Related materials as well as pre- and post-revision versions

https://kaken.nii.ac.jp/ja/search/?kw=90642356

https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K21015/

https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K21015/15K21015seika/

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Kanazawa University Repository for Academic Resources
Digital
You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
Kanazawa University Repository for Academic Resources

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 文書・図像類
Title: 新規微小管作用薬による胃癌腹膜播種線維化抑制についての実験的検討
Author/Editor: 柄田, 智也
Tsukada, Tomoya
Author Heading: 柄田, 智也
Tsukada, Tomoya
Publication Date: 2017-05-30
Publication Date (W3CDTF): 2017-05-30
Alternative Title: Effect of eribulin, a new microtubule dynamics inhibitor, for tumor progression and fibrosis in peritoneal dissemination of gastric cancer
Periodical title: 平成28(2016)年度科学研究費補助金若手研究(B) 研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2015-04-01 – 2017-03-31
Volume: 2015-04-01 – 2017-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 胃癌
腹膜播種
上皮間葉転換
線維化
低濃度エリブリン
TGFβ
smad シグナル伝達
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
胃癌腹膜播種は高度の浸潤能と線維化を伴い化学療法抵抗性を示す。今回、新規微小管重合阻害剤であるエリブリンが胃がんの進展やEMT様変化を抑制するか検討すると同時に、5FUとの併用効果についても検討した。vitroでは、エリブリンは低濃度で胃癌細胞株MKN45の増殖とEMT様変化を抑制し、5FUとの相乗効果を認めた。vivoでは、マウスヒト胃癌細胞移植腫瘍（MKN45 + HPMC ヒト腹膜中皮細胞）の増殖と線維化を抑制した。以上より、エリブリンは胃癌腹膜播種の新しい治療戦略ツールとなりうる。
Peritoneal dissemination of gastric cancer is characterized by aggressive invasion, extensive stromal fibrosis, and resulting drug-resistant tumors. We examined whether eribulin, which is a newly microtubule dynamics inhibitor, could inhibit progression and EMT changes in gastric cancer and act synergistically with 5FU. Eribulin significantly suppressed gastric cancer cell proliferation, as well as EMT changes in MKN45 gastric cancer cells and HPMCs induced by their interaction in vitro. EMT inhibition by eribulin was observed at much lower concentrations than its IC50 and resulted, at least partly, from downregulation of TGF-β/Smad signaling by interruption of Smad2 phosphorylation. Eribulin also suppressed tumor progression and fibrosis in a mouse fibrotic tumor xenograft model. Furthermore, its administration with 5FU brought about synergistic antitumor effects. Eribulin demonstrates the potential to be a key treatment for peritoneal dissemination of gastric cancer.
研究課題/領域番号:15K21015, 研究期間(年度):2015-04-01 – 2017-03-31
DOI: 10.24517/00059235
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=90642356
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K21015/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K21015/15K21015seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA