芽胞形成制御シグナルの同定と制御機構の解明

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Author: 大谷, 郁ほか

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Publication date: 2018-05-30

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Note (General)：: 東海大学 / 金沢大学医薬保健研究域医学系ウェルシュ菌は悪玉菌とよばれながらも、ヒト腸内常在菌とし存在している。　ウェルシュ菌の病原性発揮の第１段階には芽胞が重要な役割を担っているが、その形成開始のメカニズムは不明な点が多い。本研究では芽胞形成に関与するセンサータンパク候補を同定し、そのセンサーの変...

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Material Type: 文書・図像類
Title: 芽胞形成制御シグナルの同定と制御機構の解明
Author/Editor: 大谷, 郁
Otani, Kaori
Author Heading: 大谷, 郁
Otani, Kaori
Publication Date: 2018-05-30
Publication Date (W3CDTF): 2018-05-30
Alternative Title: Analysis of regulatory mechanism of sporulation and its signal in Clostridium perfringens
Periodical title: 平成29(2017)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2017 Fiscal Year Final Research Report
No. or year of volume/issue: 2015-04-01 – 2018-03-31
Volume: 2015-04-01 – 2018-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 異種間情報伝達
芽胞形成
Target Audience: 一般
Note (General): 東海大学 / 金沢大学医薬保健研究域医学系
ウェルシュ菌は悪玉菌とよばれながらも、ヒト腸内常在菌とし存在している。　ウェルシュ菌の病原性発揮の第１段階には芽胞が重要な役割を担っているが、その形成開始のメカニズムは不明な点が多い。本研究では芽胞形成に関与するセンサータンパク候補を同定し、そのセンサーの変異株では芽胞形成効率が低下し、腸管毒素遺伝子の発現も低下することが明らかとなった。ま他、腸内で共存する可能性のある酪酸菌との共培養により、酪酸菌と共存することでウェルシュ菌の芽胞形成効率が低下し、腸管毒素産生性も低下することが明らかとなり、異種の細菌からのシグナルを受けて環境に応じた遺伝子発現へと切り替えている可能性が示唆された。in Press
Clostridium perfringens causes gas gangrene and gastrointestinal (GI) diseases in humans.Spores are important factors to cause diseases but the mechanism of how to start sporulation has not been identified. One of the sensor proteins to start the sporulation was identified in this research. The mutant strain of this sensor reduced the sporulation and its complemented strain recovered the sporulation rate. Moreover, Clostridium butyricum and C. perfringens were co-cultured in the sporulation condition. These bacteria are normal flora of human intestine and have possibility to communicate to each other. A decrease in sporulation rate of C. perfringens was found, furthermore, transcription of enterotoxin gene was also found to be reduced by the co-culture with C. butyricum. These data indicated that signals from C. butyricum control the gene expression in C. perfringens. This kind of communication of bacteria in the human intestine might be very important to maintain the bacteria balance.
研究課題/領域番号:15K08460, 研究期間(年度):2015-04-01 – 2018-03-31
出典：研究課題「芽胞形成制御シグナルの同定と制御機構の解明」課題番号15K08460（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K08460/15K08460seika/）を加工して作成
DOI: 10.24517/00059364
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=30377410
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-15K08460/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-15K08460/15K08460seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA