肝細胞癌のGd-EOB-DTPA造影MRIによるsubtype分類

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Author: 北尾, 梓ほか

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Publication date: 2014-05-23

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Note (General)：: 金沢大学附属病院肝細胞癌において、肝特異性MRI造影剤Gd-EOB-DTPAはトランスポーターOATP8により細胞に取り込まれる。肝細胞癌ではOATP8の発現低下によりGd-EOB-DTPA造影MRI肝細胞相で通常低信号を示すが、10-15％の頻度でOATP8の発現が亢進し高信号を示す一群が存在する...

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https://kaken.nii.ac.jp/ja/search/?kw=20608690

https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791281

https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791281/24791281seika/

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Material Type: 文書・図像類
Title: 肝細胞癌のGd-EOB-DTPA造影MRIによるsubtype分類
Author/Editor: 北尾, 梓
Kitao, Azusa
Author Heading: 北尾, 梓
Kitao, Azusa
Publication Date: 2014-05-23
Publication Date (W3CDTF): 2014-05-23
Alternative Title: Subtype classification of hepatocellular carcinoma by Gd-EOB-DTPA enhanced magnetic resonance imaging
Periodical title: 平成25(2013)年度科学研究費補助金若手研究(B) 研究成果報告書 = 2013 Fiscal Year Final Research Report
No. or year of volume/issue: 2012-04-01 – 2014-03-31
Volume: 2012-04-01 – 2014-03-31
Pages: 5p.-
Text Language Code: jpn
Subject Heading: 肝細胞癌
subtype
MRI
Gd-EOB-DTPA
Target Audience: 一般
Note (General): 金沢大学附属病院
肝細胞癌において、肝特異性MRI造影剤Gd-EOB-DTPAはトランスポーターOATP8により細胞に取り込まれる。肝細胞癌ではOATP8の発現低下によりGd-EOB-DTPA造影MRI肝細胞相で通常低信号を示すが、10-15％の頻度でOATP8の発現が亢進し高信号を示す一群が存在する。我々はこのような信号強度の差が特定の分子病理学的背景を有するsubtypeの違いを反映していると推測し、その生物学的特徴の比較検討を行った。その結果、高信号肝癌は低信号肝癌と比較して悪性度が低く予後良好な一群であり、マーカー発現パターンより成熟肝細胞に近い性質を有するsubtypeである可能性が示された。
On the hepatobiliary phase of Gd-EOB-DTPA enhanced MR imaging (EOB-MRI), hepatocellular carcinoma (HCC) commonly shows hypointensity, however, a part of HCCs demonstrates hyperintensity caused by over-expression of OATP8, the uptake transporter of Gd-EOB-DTPA. We analyzed the correlation between the biological features and signal intensity on EOB-MRI in surgically resected HCC.Hyperintense HCC showed significantly less malignant biological features and better prognosis than those of hypointense HCC. Hyperintense HCC, namely OATP8 over-expressed HCC, is supposed to be a subtype with mature hepatocyte like molecular backgrounds.
研究課題/領域番号:24791281, 研究期間(年度):2012-04-01 – 2014-03-31
DOI: 10.24517/00059698
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=20608690
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24791281
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24791281/24791281seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA