スキルス胃癌の癌間質増生と癌性腹膜炎発症機構の本態解明

Material type: 文書・図像類

Author: 安本, 和生ほか

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Publication date: 2017-06-08

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Note (General)：: 金沢医科大学 / 金沢大学がん進展制御研究所癌の増殖や進展における癌関連間質細胞の重要性は報告があるものの、その起源と生物活性は十分に明らかにされていない。難治性疾患の代表格であり著しい発育と癌性腹膜炎の高頻度合併を特徴とするスキルス胃癌は、間質細胞の異常な増生を特徴とする。間質の異常増生こそが本病...

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Material Type: 文書・図像類
Title: スキルス胃癌の癌間質増生と癌性腹膜炎発症機構の本態解明
Author/Editor: 安本, 和生
Yasumoto, Kazuo
Author Heading: 安本, 和生
Yasumoto, Kazuo
Publication Date: 2017-06-08
Publication Date (W3CDTF): 2017-06-08
Alternative Title: Elucidation of essential molecular mechanism by which cancer stroma cause the development of peritoneal carcinomatosis into scirrhous gastric cancer
Periodical title: 平成28(2016)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2016 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 – 2017-03-31
Volume: 2014-04-01 – 2017-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 胃癌
スキルス胃癌
癌性腹膜炎
癌間質線維芽細胞
HGF/MET axis
Target Audience: 一般
Note (General): 金沢医科大学 / 金沢大学がん進展制御研究所
癌の増殖や進展における癌関連間質細胞の重要性は報告があるものの、その起源と生物活性は十分に明らかにされていない。難治性疾患の代表格であり著しい発育と癌性腹膜炎の高頻度合併を特徴とするスキルス胃癌は、間質細胞の異常な増生を特徴とする。間質の異常増生こそが本病態形成の鍵を握ると考えられる。本研究により、スキルス胃癌病態特異的な間質特性としてHGF高産生性α-SMA＋・FAP＋活性化線維芽細胞からなることが初めて明らかとなり、スキルス胃癌細胞とHGF高産生線維芽細胞が構成する癌微小環境解明が本疾患の革新的標的治療法開発につながるものと期待される。
Cancer associated fibroblasts (CAFs) play a crucial role for tumor progression in a variety of malignancy. Activated CAFs frequently express α-smooth muscle actin(SMA) and are classified as myofibroblasts. However, the role and significance of CAFs in gastric cancer progression is still unknown. We investigated the biology of CAFs in human gastric cancers, in particular scirrhous gastric cancer characterized by intense stromal fibroblasts.We demonstrated that the CAFs in primary site of scirrhous gastric cancer are composed of HGF-producing and both SMA- and fibroblast activation protein (FAP)- expressing activated fibroblasts. Thus, targeting marked HGF production in SMA+ and FAP+ CAFs of scirrhous gastric cancer may result in a clinically effective reduction of tumor progression and dissemination.
研究課題/領域番号:26461972, 研究期間(年度):2014-04-01 – 2017-03-31
DOI: 10.24517/00059373
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=90262592
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26461972/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26461972/26461972seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA