浸潤性脳腫瘍が頭頂葉-前頭葉高次機能ネットワーク再構築に及ぼす影響の検討

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Author: 林, 裕ほか

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Publication date: 2016-05-31

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Note (General)：: 金沢大学医薬保健研究域医学系前頭葉と頭頂葉を連絡する連合線維束である上縦束 Iを屍体脳において解剖学的に同定することに成功した。また、上縦束 Iが実際のヒト脳において作業記憶に関わることや脳腫瘍による機能再構築の可能性を確認しえた。これらの知見を踏まえ、従来ではnon eloquent areaある...

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Material Type: 文書・図像類
Title: 浸潤性脳腫瘍が頭頂葉-前頭葉高次機能ネットワーク再構築に及ぼす影響の検討
Author/Editor: 林, 裕
Hayashi, Yutaka
Author Heading: 林, 裕
Hayashi, Yutaka
Publication Date: 2016-05-31
Publication Date (W3CDTF): 2016-05-31
Alternative Title: Functional reorganization of the association fiber networks between dorsal frontal and parietal regions in human brain tumor surgery
Periodical title: 平成27(2015)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2015 Fiscal Year Final Research Report
No. or year of volume/issue: 2013-04-01 – 2016-03-31
Volume: 2013-04-01 – 2016-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 前頭葉
頭頂葉
連合線維束
DTI-tractography
高次脳機能
作業記憶
浸潤性脳腫瘍
覚醒下手術
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
前頭葉と頭頂葉を連絡する連合線維束である上縦束 Iを屍体脳において解剖学的に同定することに成功した。また、上縦束 Iが実際のヒト脳において作業記憶に関わることや脳腫瘍による機能再構築の可能性を確認しえた。これらの知見を踏まえ、従来ではnon eloquent areaあるいはsilent areaと呼称され、脳腫瘍摘出術においては術後の合併症に関してあまり検討されていなかった右前頭葉に位置する脳腫瘍摘出術における作業記憶の障害を解析した。結果、右前頭葉腫瘍において空間性作業記憶が障害されやすいこと、また覚醒下手術により脳機能の再構築を確認しつつ、その予防が可能となることを証明した。
The existence of the association fiber tract between the superior frontal gyrus and parietal lobe was validated for the first time using gross anatomical fiber dissection in post-mortem human brains. This tract corresponds to the superior longitudinal fasciculus I (SLF I) depicted by DTI-tractography in living human brain. The causal role of the supplementary motor area, one of terminations of the SLF I, in verbal working memory and functional reorganization with brain tumor were supported directly with functional mapping during awake surgery for the first time.Spatial working memory deficits may persist in patient who undergo resection of the tumor located in the right prefrontal brain parenchyma, which has been regarded as a silent area. Injury to the SLF I could play a causal role in the deficits. Awake surgery would be useful to detect the spatial working memory network and its reorganization during tumor exploration located in the right prefrontal region.
研究課題/領域番号:25462249, 研究期間(年度):2013-04-01 – 2016-03-31
DOI: 10.24517/00059473
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=90262568
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-25462249/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-25462249/25462249seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA