ノスカピン誘導体EM101の腎細胞癌に対する抗腫瘍効果及びそのメカニズムの検討

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Author: 宮城, 徹ほか

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Publication date: 2014-05-09

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Note (General)：: 金沢大学医薬保健研究域医学系ノスカピンは臨床的に使用可能な安全な薬であり、MDR発現癌にも抗腫瘍作用が認められている。腎癌の薬剤耐性にMDR高発現が関与すると考えられているため、腎癌細胞ACHNにノスカピンを加え、in vitro, in vivoにおいて抗腫瘍効果を確認した。前立腺癌細胞株において...

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Material Type: 文書・図像類
Title: ノスカピン誘導体EM101の腎細胞癌に対する抗腫瘍効果及びそのメカニズムの検討
Author/Editor: 宮城, 徹
Miyagi, Tohru
Author Heading: 宮城, 徹
Miyagi, Tohru
Publication Date: 2014-05-09
Publication Date (W3CDTF): 2014-05-09
Alternative Title: Effect of Noscapine and its derivative, EM101, on renal cell cancer and their mechanisms
Periodical title: 平成25(2013)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2013 Fiscal Year Final Research Report
No. or year of volume/issue: 2011 – 2013
Volume: 2011 – 2013
Pages: 4p.-
Text Language Code: jpn
Subject Heading: Noscapine
renal cell cancer
prostate cancer
flavonoids
docetaxel
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
ノスカピンは臨床的に使用可能な安全な薬であり、MDR発現癌にも抗腫瘍作用が認められている。腎癌の薬剤耐性にMDR高発現が関与すると考えられているため、腎癌細胞ACHNにノスカピンを加え、in vitro, in vivoにおいて抗腫瘍効果を確認した。前立腺癌細胞株においても抗腫瘍効果を確認し、MDR高発現しているパクリタキセル耐性前立腺癌細胞株DU145-TxRでも同様の抗腫瘍効果を観察した。さらに、前立腺癌においてノスカピンと植物フラボノイドによる相乗的効果を期待する目的で、植物フラボノイドのアンドロゲン応答性に対する抑制効果を調査し、ナリンゲニンが強い抑制作用のあることを観察した。
Noscapine is clinically available safe medicine, and antitumor action is found in MDR-overexpressing cancer. Because it was considered that MDR overexpression was involved in drug resistance of the renal carcinoma, we added Noscapine to renal carcinoma cells ACHN and confirmed antitumor effect in in vitro and in vivo. We confirmed antitumor effect in the prostate cancer cell line. Noscapine inhibited the proliferation of not only androgen-independent prostate caner cells DU145 but also DU145-TxR which is resistant for paclitaxel and docetaxel.DU145-TxR overexpressed MDR mRNA and p-glycoprotein that stimulate.For the purpose of expecting a synergistic effect with noscapine and flavonoids in prostate cancer, we investigated the effect of flavonoids on the androgen responsiveness. After LNCaP cells were transfected with PSA promoter-driven Luciferase reporter, cells were treated with DHT with flavonoids. Then naringenin showed the strong suppression of androgen responsiveness.
研究課題/領域番号:23592327, 研究期間(年度):2011 – 2013
DOI: 10.24517/00059477
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=60467107
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-23592327/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-23592327/23592327seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA