免疫調整遺伝子多型解析に基づくテーラーメード型同種造血幹細胞移植の確立

Material type: 文書・図像類

Author: 高見, 昭良ほか

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Publication date: 2015-06-15

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Note (General)：: 愛知医科大学 / 金沢大学附属病院免疫調整遺伝子多型を臨床的・機能的に解析し、CXCL10、NLRP3、PTPN22、CD53、THBD各遺伝子多型が、非血縁者間骨髄移植後転帰に影響すること、NLRP3、CD53、THBDが機能的多型であることを明らかにした。これらは、同種造血幹細胞移植にとどまらず...

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Material Type: 文書・図像類
Title: 免疫調整遺伝子多型解析に基づくテーラーメード型同種造血幹細胞移植の確立
Author/Editor: 高見, 昭良
Takami, Akiyoshi
Author Heading: 高見, 昭良
Takami, Akiyoshi
Publication Date: 2015-06-15
Publication Date (W3CDTF): 2015-06-15
Alternative Title: Establishment of tailor-made type allogeneic hematopoietic stem cell transplantation based on immune-modulating gene polymorphism analysis
Periodical title: 平成26(2014)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2014 Fiscal Year Final Research Report
No. or year of volume/issue: 2012-04-01 – 2015-03-31
Volume: 2012-04-01 – 2015-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 遺伝子多型
Target Audience: 一般
Note (General): 愛知医科大学 / 金沢大学附属病院
免疫調整遺伝子多型を臨床的・機能的に解析し、CXCL10、NLRP3、PTPN22、CD53、THBD各遺伝子多型が、非血縁者間骨髄移植後転帰に影響すること、NLRP3、CD53、THBDが機能的多型であることを明らかにした。これらは、同種造血幹細胞移植にとどまらず、自己免疫疾患や感染症、がん、臓器移植診療への波及効果も期待される。
When the impact of immune-modulating gene polymorphisms was examined in patients and their donors of unrelated hematopoietic stem cell transplantation, genetic variations in the CXCL10, NLRP3, PTPN22, CD53, and THBD genes were associated with transplant outcomes. Experimental investigation revealed that the gene polymorphisms of NLRP3, CD53 and THBD play functionally important roles in the regulation of their production. These findings may offer clinical benefits in patients with receiving allogeneic hematopoietic stem cell transplants as well as those with autoimmune diseases, infectious diseases, cancers and receiving organ transplants.
研究課題/領域番号:24591418, 研究期間(年度):2012-04-01 – 2015-03-31
DOI: 10.24517/00059542
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=80324078
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24591418/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24591418/24591418seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA