腫瘍脊椎骨全摘術後の骨欠損に対する自己脂肪由来幹細胞を用いた骨再生

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Author: 出村, 諭ほか

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Publication date: 2015-06-04

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Note (General)：: 金沢大学附属病院脊椎腫瘍切除後の動物モデルで、脂肪由来幹細胞を脊椎骨欠損部での再建材料として用い、移植骨の骨形成への関わりを評価した。その結果、移植骨内に占める線維性結合組織面積、新生骨に占める層板骨の割合、骨形成速度の比較検討で、いずれも脂肪由来幹細胞群は対照群と比較して高値となった。移植骨の骨形...

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https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24592190/24592190seika/

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Material Type: 文書・図像類
Title: 腫瘍脊椎骨全摘術後の骨欠損に対する自己脂肪由来幹細胞を用いた骨再生
Author/Editor: 出村, 諭
Demura, Satoru
Author Heading: 出村, 諭
Demura, Satoru
Publication Date: 2015-06-04
Publication Date (W3CDTF): 2015-06-04
Alternative Title: Bone healing with the adipose-derived regenerative cells in the large bone defect after total en bloc spondylectomy
Periodical title: 平成26(2014)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2014 Fiscal Year Final Research Report
No. or year of volume/issue: 2012-04-01 – 2015-03-31
Volume: 2012-04-01 – 2015-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 脊椎腫瘍
腫瘍脊椎骨全摘術
自家骨移植
自己脂肪由来幹細胞
骨癒合
脊柱再建
生物学的固定
骨欠損
Target Audience: 一般
Note (General): 金沢大学附属病院
脊椎腫瘍切除後の動物モデルで、脂肪由来幹細胞を脊椎骨欠損部での再建材料として用い、移植骨の骨形成への関わりを評価した。その結果、移植骨内に占める線維性結合組織面積、新生骨に占める層板骨の割合、骨形成速度の比較検討で、いずれも脂肪由来幹細胞群は対照群と比較して高値となった。移植骨の骨形成は線維性結合組織の増生に始まり、リモデリングを経て骨癒合に至るとされる。脂肪由来幹細胞群では対照群より早期の段階で層板骨が形成され、骨形成を促進させることができると考えられた。
We investigated whether adipose derived regenerative cells (ADRCs) promote osteogenesis of the bone graft in total en bloc spondylectomy (TES) animal model. In control group, bone formation area was occupied by woven bone 2 weeks after surgery. In ADRCs group, lamellar bone was shown in a certain proportion 2 weeks after surgery, and the ratio of lamellar bone increased in both groups 4weeks after sugery. The Number of osteoblasts lined up on the osteoid surface tended to be large in ADRCs group. Under fluorescent light, there was few deposition of calcein in control group, in the meanwhile, there were defuse deposition which showed immature lamellar structure in ADRCs group 2 weeks after surgery. The orderly label line was shown that meant mature lamellar structure in both groups 4weeks after surgery. ADRCs used as materials of spinal reconstruction promoted osteogenesis of the bone graft in the early phase.
研究課題/領域番号:24592190, 研究期間(年度):2012-04-01 – 2015-03-31
DOI: 10.24517/00059604
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=00348228
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-24592190/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-24592190/24592190seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA