脂肪由来幹細胞を用いた半月板再生

Material type: 文書・図像類

Author: 五嶋, 謙一ほか

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Publication date: 2016-05-30

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Note (General)：: 金沢大学医薬保健研究域医学系脂肪組織由来幹細胞（ADSCs）による半月板再生ついて検討した。ウサギの内側半月板に欠損を作製し、欠損部をそのままにしたコントロール群と、ADSCsの3次元培養を行い、それらを多数凝集させ欠損部に充填したADSC群で比較した。肉眼的組織連続性は、コントロール群に比しADS...

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https://kaken.nii.ac.jp/ja/search/?kw=60706886

https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26861177/

https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26861177/26861177seika/

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Material Type: 文書・図像類
Title: 脂肪由来幹細胞を用いた半月板再生
Author/Editor: 五嶋, 謙一
Goshima, Kennichi
Author Heading: 五嶋, 謙一
Goshima, Kennichi
Publication Date: 2016-05-30
Publication Date (W3CDTF): 2016-05-30
Alternative Title: Scaffold-free tissue-engineered allogenic adipose-derived stem cells promote meniscus regeneration
Periodical title: 平成27(2015)年度科学研究費補助金若手研究(B) 研究成果報告書 = 2015 Fiscal Year Final Research Report
No. or year of volume/issue: 2014-04-01 – 2016-03-31
Volume: 2014-04-01 – 2016-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 半月板再生
脂肪由来幹細胞
細胞凝集塊
スフェロイド
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
脂肪組織由来幹細胞（ADSCs）による半月板再生ついて検討した。ウサギの内側半月板に欠損を作製し、欠損部をそのままにしたコントロール群と、ADSCsの3次元培養を行い、それらを多数凝集させ欠損部に充填したADSC群で比較した。肉眼的組織連続性は、コントロール群に比しADSC群で良好な結果が得られ、組織学的にもADSC群で有意差をもってスコアが高かった(P<0.05)。また、免疫組織学的には半月板の修復部に抗Ⅰ型コラーゲンが観察され、染色性は経時的に増強する傾向を認めた。以上の結果から、ADSCsが半月板の再生を促進することが明らかになった。
Purpose: To determine whether meniscal tissue could be regenerated by the implantation of adipose-derived stem cells (ADSCs) engrafted into the meniscal defect in a rabbit model of partial meniscectomy. Methods: We created full-thickness meniscal defects in the rabbit’s knee. The defects were left empty in the control group, and were filled with ADSCs which created a 3-dimensional structure of ADSCs in the ADSC group. Results: Macroscopically, full-thickness defects remained in the control group, however, the defects were not observed in any time point in the ADSC group. Histologically, there was a consistent tendency toward significantly superior tissue quality scores in the ADSC group compared with the control group at all weeks (p<.005). Regenerated tissue was positive for type I collagen and the extent of staining increased gradually over time in the ADSC group. Conclusions: This study shows that ADSCs adhere to meniscal defect and promote meniscus regeneration.
研究課題/領域番号:26861177, 研究期間(年度):2014-04-01 – 2016-03-31
DOI: 10.24517/00059162
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=52869&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=52869&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=60706886
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-26861177/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-26861177/26861177seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA