急性脳症を誘発するスギヒラタケの脳症起因物質の探索

Material type: 文書・図像類

Author: 太田, 富久ほか

Publisher: -

Publication date: 2011-03-31

Material Format: Digital

Capacity, size, etc.: -

NDC: -

View All

Notes on use

Note (General)：: 金沢大学医薬保健研究域薬学系本研究はスギヒラタケ脳症が複数の毒性原因に基づくと仮定して検証を進め、これまでに得られた内臓障害性および炎症性を示すペプチジルポリシアル酸類縁体の精製と構造解析の結果、スギヒラタケの糖タンパクには、ヒト体内で抗原性を示すN-グリコリルノイラミン酸(NeuGc)が特異的に含...

Related materials as well as pre- and post-revision versions

https://kaken.nii.ac.jp/ja/search/?kw=50108560

https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20590004/

https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20590004/20590004seika/

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Kanazawa University Repository for Academic Resources
Digital
You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
Kanazawa University Repository for Academic Resources

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 文書・図像類
Title: 急性脳症を誘発するスギヒラタケの脳症起因物質の探索
Author/Editor: 太田, 富久
Ohta, Tomihisa
Author Heading: 太田, 富久
Ohta, Tomihisa
Publication Date: 2011-03-31
Publication Date (W3CDTF): 2011-03-31
Alternative Title: Study of encephalopathy inducing constituent in Pleurocybella porrigens
Periodical title: 平成22(2010)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2010 Fiscal Year Final Research Report
No. or year of volume/issue: 2008 – 2010
Volume: 2008 – 2010
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 生物活性物質
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域薬学系
本研究はスギヒラタケ脳症が複数の毒性原因に基づくと仮定して検証を進め、これまでに得られた内臓障害性および炎症性を示すペプチジルポリシアル酸類縁体の精製と構造解析の結果、スギヒラタケの糖タンパクには、ヒト体内で抗原性を示すN-グリコリルノイラミン酸(NeuGc)が特異的に含まれていることを明らかにし、スギヒラタケ脳症への関与を示唆した。一方、腸管上皮細胞障害性と神経組織への障害性が考えられる低分子成分であるスフィンゴ糖脂質の絶対構造を決定し化学合成を行った。
This study was focused on the supposition that Angel Wing (Pleurocybella porrigens) brain disorder was based on plural toxic causes. The refinement and the structural analysis of the peptidyl polysialic analogues having internal organs disorder characteristics and inflammatory nature showed that N-glycolyl neuraminic acid (NeuGc) indicating the antigenicity was specifically included in the glycoprotein of the Angel Wing. On the other hand, the structure of sphingoglycolipid A was determined and synthesized. Sphingoglycolipid A was presumed on impaired characteristics to the nervous system and intestinal epithelia.
研究課題/領域番号:20590004, 研究期間(年度):2008 – 2010
出典：研究課題「急性脳症を誘発するスギヒラタケの脳症起因物質の探索」課題番号20590004（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20590004/20590004seika/）を加工して作成
DOI: 10.24517/00059787
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=50108560
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-20590004/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-20590004/20590004seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA