長期抗HIV療法が小児免疫状態に及ぼす影響

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Author: 畢, 袖晴ほか

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Publication date: 2020-05-21

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Note (General)：: 金沢大学医薬保健研究域医学系本研究は長期ART(antiretroviral therapy)が小児の免疫状態に及ぼす影響の解明を目的とした。ART導入後、小児のCD4-RTE/-naive/-cm/-em とTh1 サブセット, CD8-naive/-cm サブセットは6ヶ月までに非感染児の正常レ...

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Material Type: 文書・図像類
Title: 長期抗HIV療法が小児免疫状態に及ぼす影響
Author/Editor: 畢, 袖晴
Bi, Xiuqiong
Author Heading: 畢, 袖晴
Bi, Xiuqiong
Publication Date: 2020-05-21
Publication Date (W3CDTF): 2020-05-21
Alternative Title: Long-term impact of ART on immune status of HIV-infected children
Periodical title: 令和1(2019)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2019 Fiscal Year Final Research Report
No. or year of volume/issue: 2017-04-01 - 2020-03-31
Volume: 2017-04-01 - 2020-03-31
Pages: 8p.-
Text Language Code: jpn
Subject Heading: HIV
ART
小児
免疫状態
Pediatrics
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
本研究は長期ART(antiretroviral therapy)が小児の免疫状態に及ぼす影響の解明を目的とした。ART導入後、小児のCD4-RTE/-naive/-cm/-em とTh1 サブセット, CD8-naive/-cm サブセットは6ヶ月までに非感染児の正常レベルに上昇した。他のCD4とCD8細胞のサブセット、Th2/Th17/Treg、CD8細胞の活性化、CD4/CD8比はART後1-4年目までに正常化した。ARTによりHIV感染小児の胸腺機能は早期に回復したが、CD4/CD8比の正常化には４年必要であった。ART前の年齢は小さいほどART後6ヶ月のCD4細胞増加数が多かった。
This study investigated the impact of ART on the immune status of HIV-infected Vietnamese children. The differentiation of CD4 and CD8 cells, Th1/Th2/Th17/Treg subsets, and CD8 T cell activation were analyzed twice a year and compared to those of HIV-uninfected children.After ART initiation, the CD4 cell counts including the CD4-RTE (recent thymic emigrants)/-naive/-cm (central memory)/-em (effector memory) and Th1 subsets, and the CD8-naive/-cm subset counts significantly increased and reached the HIV(─) children’s range by 6 months. The CD4-emra (emCD45RA+) and Th2/Th17/Treg, the activated CD8 cells, the CD8-em/-emra subsets, the CD4/CD8 ratio normalized within 4 years. The younger children showed better increase of CD4 counts at 6 months of ART. ART induced an early recovery of thymic function in HIV-infected children and lead to the early recovery of CD4 and CD8 naive subsets. Early diagnose of HIV infection followed by early ART is important for HIV administration in children.
研究課題/領域番号:17K10100, 研究期間(年度):2017-04-01 - 2020-03-31
出典：「長期抗HIV療法が小児免疫状態に及ぼす影響」研究成果報告書　課題番号17K10100（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10100/17K10100seika/)を加工して作成
DOI: 10.24517/00057449
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=50565413
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10100/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10100/17K10100seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA