口腔癌の高浸潤性獲得メカニズムと微小管の関連解析

Material type: 文書・図像類

Author: 北原, 寛子ほか

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Publication date: 2020-05-14

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Note (General)：: 金沢大学附属病院歯科口腔外科本研究では、微小管阻害薬であるエリブリン，パクリタキセル，ビンブラスチンの効果を，高浸潤頭頸部扁平上皮癌（OLC01，OSC-19）細胞を用いて検討した．結果，エリブリンがOLC01細胞に対して，パクリタキセルやビンブラスチンよりも高い感受性があることを明らかにした．また...

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Material Type: 文書・図像類
Title: 口腔癌の高浸潤性獲得メカニズムと微小管の関連解析
Author/Editor: 北原, 寛子
Kitahara, Hiroko
Author Heading: 北原, 寛子
Kitahara, Hiroko
Publication Date: 2020-05-14
Publication Date (W3CDTF): 2020-05-14
Alternative Title: Association analysis of microtubules and the mechanism of highly invasive acquisition in oral cancer
Periodical title: 令和1(2019)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2019 Fiscal Year Final Research Report
No. or year of volume/issue: 2017-04-01 - 2020-03-31
Volume: 2017-04-01 - 2020-03-31
Pages: 8p.-
Text Language Code: jpn
Subject Heading: 口腔扁平上皮癌
微小管阻害薬
Surgical dentistry
Target Audience: 一般
Note (General): 金沢大学附属病院歯科口腔外科
本研究では、微小管阻害薬であるエリブリン，パクリタキセル，ビンブラスチンの効果を，高浸潤頭頸部扁平上皮癌（OLC01，OSC-19）細胞を用いて検討した．結果，エリブリンがOLC01細胞に対して，パクリタキセルやビンブラスチンよりも高い感受性があることを明らかにした．また，エリブリンの高感受性はTUBB3の発現低下と相関していた．マウスの舌にOLC01を移植し，微小管阻害薬を投与，エリブリンは高い増殖抑制作用を示した．以上の結果より，エリブリンは高浸潤頭頸部癌に選択的に高感受性を示す可能性が示唆され，エリブリンの頭頸部癌への適応拡大の可能性があると考えられた．
In the present study, the effects of eribulin, paclitaxel and vinblastine were investigated in recurrent and/or metastatic squamous cell carcinoma of the head and neck （R/M SCCHN）(OLC-01 and OSC-19) . Eribulin was highly sensitive to OLC01 cells in comparison with paclitaxel and vinblastine. The reduced expression of Tubulin Beta 3 Class III　following treatment was correlated with a high sensitivity to eribulin. The anticancer effect of eribulin, paclitaxel and vinblastine were evaluated in OLC01 human R/M SCCHN xenograft models using mice. Eribulin exhibits significant and superior in vivo anticancer efficacy at much lower concentrations than paclitaxel and vinblastine.In conclusion, the present study suggested that eribulin may be selectively sensitive to R/M SCCHN． As a clinically approved drug, the continued investigation of the preclinical antitumor attributes of eribulin may significantly contribute to future progress in identifying novel uses of eribulin against R/M SCCHN.
研究課題/領域番号:17K11870, 研究期間(年度):2017-04-01 - 2020-03-31
出典：「口腔癌の高浸潤性獲得メカニズムと微小管の関連解析」研究成果報告書　課題番号17K11870（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K11870/17K11870seika/）を加工して作成
DOI: 10.24517/00058031
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=70507053
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K11870/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K11870/17K11870seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA