関節不動に伴う筋線維芽細胞の発現と治療手技の効果判定

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Author: 松崎, 太郎ほか

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Publication date: 2020-05-26

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Note (General)：: 金沢大学医薬保健研究域保健学系関節可動域運動の効果を角度だけではなく組織の線維化を生じるとされる筋線維芽細胞の変化に着目して実験を行った。ラットの後肢を不動化した群，徒手的に可動域運動を行った群、対照群を作成し角度と関節構成体の変化を観察した。運動群の可動域制限は不動群に対して有意に少なかったが対照...

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Material Type: 文書・図像類
Title: 関節不動に伴う筋線維芽細胞の発現と治療手技の効果判定
Author/Editor: 松崎, 太郎
Matuzaki, Taro
Author Heading: 松崎, 太郎
Matuzaki, Taro
Publication Date: 2020-05-26
Publication Date (W3CDTF): 2020-05-26
Alternative Title: Expression of myofibroblasts associated with joint immobility and evaluation of efficacy of therapeutic procedures
Periodical title: 令和1(2019)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2019 Fiscal Year Final Research Report
No. or year of volume/issue: 2016-04-01 – 2020-03-31
Volume: 2016-04-01 – 2020-03-31
Pages: 5p.-
Text Language Code: jpn
Subject Heading: 関節可動域制限
関節可動域運動
ラット
筋線維芽細胞
Rehabilitation science
Welfare engineering
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域保健学系
関節可動域運動の効果を角度だけではなく組織の線維化を生じるとされる筋線維芽細胞の変化に着目して実験を行った。ラットの後肢を不動化した群，徒手的に可動域運動を行った群、対照群を作成し角度と関節構成体の変化を観察した。運動群の可動域制限は不動群に対して有意に少なかったが対照群に対して有意に大きい結果となった。関節構成体の変化では不動群で関節腔内に肉芽様細胞の侵入、滑膜との癒着が観察されたが実験群では軽度であった。関節包内の筋線維芽細胞の発現は運動群と対照群で差は見られなかった。
We conducted an experiment focusing on changes in myofibroblasts, which are believed to cause tissue fibrosis, as well as the effect of range of motion exercise.The groups in which the hind limbs of the rat were immobilized, the group in which the range of motion was manually performed, and the control group were prepared, and changes in angle and joint constituents were observed.The range of motion limitation in the exercise group was significantly smaller than that in the immobility group, but was significantly greater than that in the control group. With regard to changes in joint composition, granulation-like cells invaded into the joint cavity and adhesion with synovium were observed in the immobility group, but they were mild in the experimental group. The expression of myofibroblasts in the joint capsule was not different between the exercise group and the control group.
研究課題/領域番号:16K01450, 研究期間(年度):2016-04-01 – 2020-03-31
出典：「関節不動に伴う筋線維芽細胞の発現と治療手技の効果判定」研究成果報告書　課題番号16K01450（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K01450/16K01450seika/)を加工して作成
DOI: 10.24517/00058687
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=10401910
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K01450/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-16K01450/16K01450seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA