血管内皮細胞が肝発がん・再発に関わるメカニズムの解明

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Author: 西川, 昌志ほか

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Publication date: 2020-07-15

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Note (General)：: 独立行政法人国立病院機構 / 金沢大学附属病院C型肝炎ウイルス排除達成（SVR）群とSVR後肝癌群の網羅的メチル化解析、および発現量解析にて今回TMEMを同定した。TMEMは新規かつ機能未知の遺伝子である。TMEMは腫瘍浸潤血管内皮細胞に発現が見られ、TMEM高発現群で有意に肝癌無再発期間が短期であ...

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Material Type: 文書・図像類
Title: 血管内皮細胞が肝発がん・再発に関わるメカニズムの解明
Author/Editor: 西川, 昌志
Nishikawa, Masashi
Author Heading: 西川, 昌志
Nishikawa, Masashi
Publication Date: 2020-07-15
Publication Date (W3CDTF): 2020-07-15
Alternative Title: Elucidation of the mechanism by which vascular endothelial cells are involved in liver carcinogenesis/recurrence
Periodical title: 令和1(2019)年度科学研究費補助金若手研究研究成果報告書 = 2019 Fiscal Year Final Research Report
No. or year of volume/issue: 2018-04-01 – 2020-03-31
Volume: 2018-04-01 – 2020-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 肝発がん
SVR
メチル化
Basic Section 53010:Gastroenterology-related
Target Audience: 一般
Note (General): 独立行政法人国立病院機構 / 金沢大学附属病院
C型肝炎ウイルス排除達成（SVR）群とSVR後肝癌群の網羅的メチル化解析、および発現量解析にて今回TMEMを同定した。TMEMは新規かつ機能未知の遺伝子である。TMEMは腫瘍浸潤血管内皮細胞に発現が見られ、TMEM高発現群で有意に肝癌無再発期間が短期であった。TMEM過剰発現血管内皮細胞は、腫瘍形成を有意に亢進することが確認できた。TMEMは、ERストレス経路を介して腫瘍形成を亢進することが示された。TMEMは、肝発がん及び肝細胞癌の治療標的になり得ることが示唆された。
We identified TMEM this time by comprehensive methylation analysis of the group achieving sustained viral response (SVR) and HCC group after achieving SVR, and expression level analysis. TMEM is a novel gene of unknown function. TMEM was found to be expressed in tumor-infiltrating vascular endothelial cells, and the recurrence-free period of liver cancer was significantly short in the high TMEM-expressing group. It was confirmed that TMEM-overexpressing vascular endothelial cells significantly promote tumor formation. TMEM has been shown to enhance tumorigenesis via the ER stress pathway. It was suggested that TMEM could be a therapeutic target for liver carcinogenesis and hepatocellular carcinoma.
研究課題/領域番号:18K15777, 研究期間(年度):2018-04-01 – 2020-03-31
出典：「血管内皮細胞が肝発がん・再発に関わるメカニズムの解明」研究成果報告書　課題番号18K15777（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15777/18K15777seika/)を加工して作成
DOI: 10.24517/00058792
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/ja/search/?kw=90794511
https://kaken.nii.ac.jp/ja/grant/KAKENHI-PROJECT-18K15777/
https://kaken.nii.ac.jp/ja/report/KAKENHI-PROJECT-18K15777/18K15777seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA