IgG4関連血管病変の進展・予後因子の解明

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Author: 笠島, 里美ほか

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Publication date: 2020-05-22

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Note (General)：: 金沢大学医薬保健研究域保健学系IgG4-AAAの外膜におけるMMPs発現は，動脈瘤の形成と進行のみならず，線維性外膜のリモデリングとの関連が示唆された．血管内治療後のIgG4-AAA の中で，術後IgG4上昇を示す群は，術前IL-6高値，術後瘤径拡大を示し，進行傾向のある高リスク群であった．この群は...

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Material Type: 文書・図像類
Title: IgG4関連血管病変の進展・予後因子の解明
Author/Editor: 笠島, 里美
Kasashima, Satomi
Author Heading: 笠島, 里美
Kasashima, Satomi
Publication Date: 2020-05-22
Publication Date (W3CDTF): 2020-05-22
Alternative Title: Prognostic factors of IgG4-related vascular disease
Periodical title: 令和1(2019)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2019 Fiscal Year Final Research Report
No. or year of volume/issue: 2017-04-01 – 2020-03-31
Volume: 2017-04-01 – 2020-03-31
Pages: 7p.-
Text Language Code: jpn
Subject Heading: IgG4関連疾患
IgG4関連大動脈瘤
外膜肥厚
matrix metalloproteinase
Cardiovascular surgery
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域保健学系
IgG4-AAAの外膜におけるMMPs発現は，動脈瘤の形成と進行のみならず，線維性外膜のリモデリングとの関連が示唆された．血管内治療後のIgG4-AAA の中で，術後IgG4上昇を示す群は，術前IL-6高値，術後瘤径拡大を示し，進行傾向のある高リスク群であった．この群は，術前IgG4／IgG比，血清MMP-9，単球，好酸球の比率がいずれも高く，これらはIgG4-AAAの術前予後予測因子の候補である．
MMP-9 production in various immune-cells of the adventitia was characteristic of IgG4-AAA and was highly associated with the activity of IgG4-AAA. MMPs expression in the adventitia of IgG4-AAA may be involved in lymphoid follicle formation and not only in the formation and progression of aneurysms, but also in the remodeling of the thick fibrous adventitia.After intravascular treatment, among the IgG4-AAA, the IgG4-AAA-up group (serum IgG4 increasing after treatment) showed a preoperative high IL-6 and an increase of postoperative aneurysm diameter. Thus, the IgG4-AAA-up group was thought to be as a high-risk group with a progressive tendency. The IgG4-AAA-up group is characterized by high preoperative IgG4 / IgG ratio, high MMP-9, and high monocyte to eosinophil ratio. These indicators are candiate of prognostic factors for IgG4-AAA.
研究課題/領域番号:17K10773, 研究期間(年度):2017-04-01 – 2020-03-31
出典：「IgG4関連血管病変の進展・予後因子の解明」研究成果報告書　課題番号17K10773（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10773/17K10773seika/)を加工して作成
DOI: 10.24517/00059044
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=20444200
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10773/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-17K10773/17K10773seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA