右前頭葉機能の賦活・抑制に関わる新規神経機能ネットワークの解明

Material type: 文書・図像類

Author: 中嶋, 理帆ほか

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Publication date: 2021-06-01

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Note (General)：: 金沢大学医薬保健研究域保健学系本研究プロジェクトの目的は，右前頭葉機能の賦活・抑制に関わる神経機能ネットワークの解明である．本研究では覚醒下手術，画像統計解析，および白質解剖という手法を用いて，脳の抑制に関わる機能と領域を明らかにした．本研究で解明した機能は，感情理解の抑制に関わる前頭前野内側と下前...

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Material Type: 文書・図像類
Title: 右前頭葉機能の賦活・抑制に関わる新規神経機能ネットワークの解明
Author/Editor: 中嶋, 理帆
Nakajima, Riho
Author Heading: 中嶋, 理帆
Nakajima, Riho
Publication Date: 2021-06-01
Publication Date (W3CDTF): 2021-06-01
Alternative Title: Neural network for activation and inhibition of right frontal lobe function
Periodical title: 令和2(2020)年度科学研究費補助金挑戦的研究(萌芽) 研究成果報告書 = 2020 Fiscal Year Final Research Report
No. or year of volume/issue: 2019-06-28 – 2021-03-31
Volume: 2019-06-28 – 2021-03-31
Pages: 11p.-
Text Language Code: jpn
Subject Heading: 右前頭葉
賦活
抑制
ネットワーク
覚醒下手術
画像統計解析
脳腫瘍
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域保健学系
本研究プロジェクトの目的は，右前頭葉機能の賦活・抑制に関わる神経機能ネットワークの解明である．本研究では覚醒下手術，画像統計解析，および白質解剖という手法を用いて，脳の抑制に関わる機能と領域を明らかにした．本研究で解明した機能は，感情理解の抑制に関わる前頭前野内側と下前頭回眼窩部，注意の制御に関わる帯状回Zone II，運動の制御に関わる前頭斜走路後方成分である．感情理解は抑制に関わる領域の損傷により，相対する感情が顕著になった．注意と運動機能については抑制に関わる領域が障害されると，注意障害と一過性の麻痺が生じた．本研究成果はリハビリテーションの治療プログラムに応用できる可能性がある．
The purpose of this study is to reveal the neural networks involved in activation and inhibition of right frontal lobe functions. In this study, we used the techniques of awake surgery, statistical analysis of images, and fiber dissection to clarify the functions and regions of the brain involved in inhibition. We found following results: the medial prefrontal cortex and the orbitofrontal region of the inferior frontal gyrus were involved in the inhibition of emotional understanding, Zone II of the cingulate gyrus related to control of attention, and the posterior component of the frontal aslant tract was involved in the control of movement. Emotional recognition was markedly different due to damage to areas involved in inhibition. For attention and motor functions, damage to the inhibitory regions caused attention deficits and transient paralysis, respectively. The results of current study may be applicable to rehabilitation programs.
研究課題/領域番号:19K22801, 研究期間(年度):2019-06-28 – 2021-03-31
出典：「右前頭葉機能の賦活・抑制に関わる新規神経機能ネットワークの解明」研究成果報告書　課題番号19K22801（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/en/report/KAKENHI-PROJECT-19K22801/19K22801seika/）を加工して作成
DOI: 10.24517/00058404
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=60614865
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22801/
https://kaken.nii.ac.jp/en/report/KAKENHI-PROJECT-19K22801/19K22801seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA