EBV関連リンパ増殖性疾患発症とKIRの関連

Material type: 文書・図像類

Author: 岩城, 憲子ほか

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Publication date: 2021-05-11

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Note (General)：: 金沢大学医薬保健研究域医学系EBV-LPD(EB virus-associated lymphoproliferative disorder)を発症した患者の全血におけるEBV-DNA copy数を定量的PCRで評価すると共にEBV-LPDを発症した患者と、EBVに関連しない悪性リンパ腫患者、健常人...

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https://kaken.nii.ac.jp/search/?qm=10825706

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17825/

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Material Type: 文書・図像類
Title: EBV関連リンパ増殖性疾患発症とKIRの関連
Author/Editor: 岩城, 憲子
Iwaki, Noriko
Author Heading: 岩城, 憲子
Iwaki, Noriko
Publication Date: 2021-05-11
Publication Date (W3CDTF): 2021-05-11
Alternative Title: Association of KIR genotype profile on the development of EBV-related iatrogenic immunodeficiency-associated lymphoproliferative disorders
Periodical title: 令和2(2020)年度科学研究費補助金若手研究研究成果報告書 = 2020 Fiscal Year Final Research Report
No. or year of volume/issue: 2019-04-01 - 2021-03-31
Volume: 2019-04-01 - 2021-03-31
Pages: 5p.-
Text Language Code: jpn
Subject Heading: EBV関連リンパ増殖性疾患
KIR遺伝子プロフィル
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
EBV-LPD(EB virus-associated lymphoproliferative disorder)を発症した患者の全血におけるEBV-DNA copy数を定量的PCRで評価すると共にEBV-LPDを発症した患者と、EBVに関連しない悪性リンパ腫患者、健常人の3群間でKIR 遺伝子プロフィルを比較し、EBV-LPDとKIR遺伝子プロフィルの関係を検討した。結果EBV-LPDを発症した患者では、活性型KIRであるKIR2DS1、KIR2DS5、抑制型KIRである2DL5の保有率が有意に低値であった。患者のKIR 遺伝子プロフィルがEBV-LPDの発症に影響する可能性が示唆された。
To identify the association between KIR gene polymorphisms and susceptibility to EBV-LPD (EB virus-associated lymphoproliferative disorder), we determined EBV copy numbers in the whole blood of patients suspected of having EBV-LPD using quantitative real-time PCR, and determined the KIR gene profile of these patients as well as those who develop non-EBV associated lymphoma and healthy individuals using PCR with specific primers. In patients with EBV-LPD, the frequencies of KIR2DS1, 2DS5 and 2DL5 were significantly lower than those in healthy individuals and non-EBV associated lymphoma. The result suggests that the KIR gene repertoire may be associated with susceptibility to EBV-LPD.
研究課題/領域番号:19K17825, 研究期間(年度):2019-04-01 - 2021-03-31
出典：「EBV関連リンパ増殖性疾患発症とKIRの関連」研究成果報告書　課題番号19K17825（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17825/19K17825seika/）を加工して作成
DOI: 10.24517/00057817
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=10825706
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17825/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-19K17825/19K17825seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA