Investigation of putative roles for GSK3b in glioblastoma stemness phenotype and the underlying biological mechanisms

Material type: 文書・図像類

Author: Pyko, Ilyaほか

Publisher: 金沢大学がん進展制御研究所

Publication date: 2021-01-27

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Note (General)：: Studies in vitro and in animal model were carried out complementary to optimize treatment of glioblastoma (GBM) by enhancing anti-tumor effect by comb...

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Material Type: 文書・図像類
Title: Investigation of putative roles for GSK3b in glioblastoma stemness phenotype and the underlying biological mechanisms
Author/Editor: Pyko, Ilya
ピコ, イリア
Author Heading: Pyko, Ilya
ピコ, イリア
Publication, Distribution, etc.: 金沢大学がん進展制御研究所
Publication Date: 2021-01-27
Publication Date (W3CDTF): 2021-01-27
Periodical title: 令和1(2019)年度科学研究費補助金若手研究研究概要 = 2019 Research Project Summary
No. or year of volume/issue: 2018-04-01 - 2020-03-31
Volume: 2018-04-01 - 2020-03-31
Pages: 2p.-
Text Language Code: jpn
Subject Heading: glioblastoma
temozolomide
GBM stem-like cells
GSK3β
cancer stem-like cells
Basic Section 56010:Neurosurgery-related
Target Audience: 一般
Note (General): Studies in vitro and in animal model were carried out complementary to optimize treatment of glioblastoma (GBM) by enhancing anti-tumor effect by combination of GSK3β inhibition and temozolomide (TMZ). For in vitro study, we examined effect of GSK3β inhibition and TMZ on patient derived GBM stem-like cells (SCs). I found that GSK3β inhibition enhances effect of TMZ against GBM-SCs and participate in regulation of GBM stemness phenotype. For animal model study, I have developed software pharmacokinetics model and determined optimal concentration of GSK3β inhibitor for continuous intra-tumor infusion by subcutaneous pumps for treatment of orthotopic GBM models and examined the effects of continuous intra-tumor infusion of GSK3β inhibitor, against GBM in mice bearing human GBM-SCs. Our experiments showed that GSK3β inhibition is effective for treatment of experimental GBM generated by inoculation of most malignant GBM-SCs characterized by shortest survival in control animals. We investigated biological mechanisms by which GSK3β regulate GBM stemness phenotype and revealed changes in stem cell markers’ expression in GBM-SCs under GSK3β inhibition, which can be associated with regulation of GBM stemness phenotype by GSK3β via multiple signaling pathways.
研究課題/領域番号:18K16553, 研究期間(年度):2018-04-01 - 2020-03-31
出典：「Investigation of putative roles for GSK3b in glioblastoma stemness phenotype and the underlying biological mechanisms」研究成果報告書　課題番号18K16553（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K16553/）を加工して作成
DOI: 10.24517/00057537
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=00731853
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16553/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA